Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 양철수 | - |
dc.date.accessioned | 2019-11-24T14:37:37Z | - |
dc.date.available | 2019-11-24T14:37:37Z | - |
dc.date.issued | 2017-04 | - |
dc.identifier.citation | JOURNAL OF IMMUNOLOGY, v. 198, no. 8, page. 3283-3295 | en_US |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.issn | 1550-6606 | - |
dc.identifier.uri | https://www.jimmunol.org/content/198/8/3283 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/113695 | - |
dc.description.abstract | The role of peroxisome proliferator-activated receptor a (PPAR-alpha) in innate host defense is largely unknown. In this study, we show that PPAR-alpha is essential for antimycobacterial responses via activation of transcription factor EB (TFEB) transcription and inhibition of lipid body formation. PPAR-alpha deficiency resulted in an increased bacterial load and exaggerated inflammatory responses during mycobacterial infection. PPAR-alpha agonists promoted autophagy, lysosomal biogenesis, phagosomal maturation, and antimicrobial defense against Mycobacterium tuberculosis or M. bovis bacillus Calmette-Guerin. PPAR-alpha agonists regulated multiple genes involved in autophagy and lysosomal biogenesis, including Lamp2, Rab7, and Tfeb in bone marrow-derived macrophages. Silencing of TFEB reduced phagosomal maturation and antimicrobial responses, but increased macrophage inflammatory responses during mycobacterial infection. Moreover, PPAR-alpha activation promoted lipid catabolism and fatty acid beta-oxidation in macrophages during mycobacterial infection. Taken together, our data indicate that PPAR-alpha mediates antimicrobial responses to mycobacterial infection by inducing TFEB and lipid catabolism. | en_US |
dc.description.sponsorship | This work was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, Ministry of Health and Welfare, Republic of Korea (HI15C0395), by the National Research Foundation grant funded by the Korean government (MSIP) (NRF-2015M3C9A2054326) at Chungnam National University. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | en_US |
dc.subject | MYCOBACTERIUM-TUBERCULOSIS | en_US |
dc.subject | LYSOSOMAL BIOGENESIS | en_US |
dc.subject | PHAGOSOME MATURATION | en_US |
dc.subject | AUTOPHAGY GENES | en_US |
dc.subject | RECEPTOR | en_US |
dc.subject | METABOLISM | en_US |
dc.subject | IMMUNITY | en_US |
dc.subject | GAMMA | en_US |
dc.subject | INFLAMMATION | en_US |
dc.subject | MACROPHAGES | en_US |
dc.title | PPAR-alpha Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism | en_US |
dc.type | Article | en_US |
dc.relation.no | 8 | - |
dc.relation.volume | 198 | - |
dc.identifier.doi | 10.4049/jimmunol.1601920 | - |
dc.relation.page | 3283-3295 | - |
dc.relation.journal | JOURNAL OF IMMUNOLOGY | - |
dc.contributor.googleauthor | Kim, Yi Sak | - |
dc.contributor.googleauthor | Lee, Hye-Mi | - |
dc.contributor.googleauthor | Kim, Jin Kyung | - |
dc.contributor.googleauthor | Yang, Chul-Su | - |
dc.contributor.googleauthor | Kim, Tae Sung | - |
dc.contributor.googleauthor | Jung, Mingyu | - |
dc.contributor.googleauthor | Jin, Hyo Sun | - |
dc.contributor.googleauthor | Kim, Sup | - |
dc.contributor.googleauthor | Jang, Jichan | - |
dc.contributor.googleauthor | Oh, Goo Taeg | - |
dc.relation.code | 2017003619 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | chulsuyang | - |
dc.identifier.orcid | https://orcid.org/0000-0003-4918-961X | - |
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