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Separations of spherical and disc-shaped polystyrene particles and blood components (red blood cells and platelets) using pinched flow fractionation device with a tilted sidewall and vertical focusing channels (t-PFF-v)

Title
Separations of spherical and disc-shaped polystyrene particles and blood components (red blood cells and platelets) using pinched flow fractionation device with a tilted sidewall and vertical focusing channels (t-PFF-v)
Author
윤태현
Keywords
Microfluidics; Non-spherical particle separation; Blood separation; Pinched flow fabrication; Fabrication of disc shaped particles
Issue Date
2017-04
Publisher
ELSEVIER SCIENCE SA
Citation
SENSORS AND ACTUATORS B-CHEMICAL, v. 249, page. 131-141
Abstract
Shape-based separation capabilities of a novel pinched flow fractionation device with a tilted sidewall and vertical focusing channels (t-PFF-v) were demonstrated for (1) spherical and disc-shaped polystyrene (PS) particles; (2) platelets (PLT) and red blood cells (RBC); and (3) singlet, doublet, and triplet clusters of disc-shaped PS particles. The tilted sidewalls and vertical focusing channels of the t-PFF-v device allowed us to perform enhanced separation of non-spherical particles. Using this t-PFF-v device with a W-p (pinched segment width) of 20 mu m and 15 mu m, not only spherical (diameter of 2 mu m) and disc-shaped (thickness of similar to 2 mu m, diameter of similar to 5.0 mu m) PS particles but also PLTs and RBCs from diluted blood were well separated with good separation resolutions (R-disc.sphere = 1.40 and R-PLT.RBC = 1.28). Additionally, time-lapse images of flowing particles indicated that both disc-shaped PS particles and RBCs are probably having type I orientation in the pinched segment (i.e., leaning against the tilted sidewalls at the pinched segment). Moreover, we observed streamlines of singlet, doublet, and triplet clustered disc-shaped PS particles, which suggested that these clustered particles could be well separated according to their aspect ratio. The doublet or triplet clustered PS particles are probably lay on the floor and rotated at the pinched segment (type II orientation). We believe that this shape-based separation capability achieved by the tPFF-v device can be utilized for many application areas, such as medical, biological, material and colloidal sciences. (C) 2017 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0925400517306810?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/113676
ISSN
0925-4005
DOI
10.1016/j.snb.2017.04.081
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > CHEMISTRY(화학과) > Articles
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