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Individual case review in a phase 3 randomized trial to investigate the role of internal mammary lymph node irradiation for breast cancer: Korean Radiation Oncology Group 08-06 study

Title
Individual case review in a phase 3 randomized trial to investigate the role of internal mammary lymph node irradiation for breast cancer: Korean Radiation Oncology Group 08-06 study
Author
정윤선
Keywords
Internal mammary node irradiation; Individual cases review; Protocol-compliance; Radiation therapy quality assurance
Issue Date
2017-04
Publisher
ELSEVIER IRELAND LTD
Citation
RADIOTHERAPY AND ONCOLOGY, v. 123, no. 1, page. 15-21
Abstract
Purpose/objective: This study aimed to assess protocol compliance based on an individual case review (ICR) of the Korean Radiation Oncology Group-0806 trial. Methods and materials: For the ICR, 747 participants were divided into eight subgroups based on internal mammary node irradiation (IMNI), tumor laterality, and surgery type. Next, 15% of patients were randomly selected within each subgroup, and corresponding hospitals were subsequently requested to upload information related to radiation therapy (RT) planning. We reviewed the dose distributions of targets and organs at risk to determine protocol compliance. Results: Data of 102 patients were collected. Overall, RT plans were found to be mostly protocol compliant, with acceptability rates of 60-80% despite deviations in the ipsilateral lung in Arm 2 (IMNI group). However, despite few deviations, a subgroup analysis revealed significant differences in protocol compliance. Among RT techniques, plans using standard and partial wide tangents were most compliant in both Arms. In this ICR, the estimated survival benefits based on IMN doses were 7.7%, 8.4%, and 7.2% for all, breast-conserving surgery, and mastectomy cases, respectively. Conclusion: This ICR demonstrated overall protocol compliance, despite significant differences with regard to IMN irradiation and organs at risk according to subgroups and adopted field arrangements. (C) 2017 Elsevier B.V. All rights reserved.
URI
https://www.thegreenjournal.com/article/S0167-8140(17)30045-2/fulltexthttps://repository.hanyang.ac.kr/handle/20.500.11754/113571
ISSN
0167-8140
DOI
10.1016/j.radonc.2017.01.017
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > NUCLEAR ENGINEERING(원자력공학과) > Articles
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