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Association between BANK1 polymorphisms and susceptibility to autoimmune diseases: A meta-analysis

Title
Association between BANK1 polymorphisms and susceptibility to autoimmune diseases: A meta-analysis
Author
배상철
Keywords
Autoimmune diseases; BANK1; Polymorphism; Meta-analysis
Issue Date
2017-03
Publisher
C M B ASSOC
Citation
CELLULAR AND MOLECULAR BIOLOGY, v. 63, no. 3, page. 29-35
Abstract
This study aimed to explore whether BANK1 polymorphisms are associated with susceptibility to autoimmune diseases. We conducted a meta-analysis on the associations between the BANK1 rs10516487, rs3733197, and rs17266594 polymorphisms and autoimmune diseases. Twenty-two articles with a total of 22,684 patients and 36,437 controls were included in the meta-analysis. Meta-analysis revealed a significant association between autoimmune diseases and the BANK1 rs10516487 T allele (OR = 1.161, 95% CI = 1.092-1.275, p = 1.9 x 10(-6), heterogeneity p < 0.001). The analysis also revealed an association between autoimmune diseases and the BANK1 rs3733197 A allele (OR = 1.178, 95% CI = 1.105-1.256, p = 4.5 x 10(-7), heterogeneity p = 0.002) and the rs17266594 T allele (OR = 1.189, 95% CI = 1.073-1.315, p = 0.001, heterogeneity p < 0.001). Meta-analysis by autoimmune disease type revealed an association between both systemic lupus erythematosus and systemic sclerosis and the BANK1 rs10516487 T allele (OR - 1.294, 95% CI - 1.232-1.360, p < 1.0 x 10(-8), heterogeneity p - 0.556; OR = 1.102, 95% CI = 1.027-1.183, p = 0.017, heterogeneity p = 0.048). However, meta-analysis failed to indicate an association between the BANK1 rs10516487 T allele and rheumatoid arthritis (RA; OR = 1.006, 95% CI = 1.956-1.058, p = 0.819). This meta-analysis demonstrates that BANK1 rs10516487, rs3733197, and rs17266594 polymorphisms are associated with susceptibility to autoimmune diseases.
URI
https://www.cellmolbiol.org/index.php/CMB/article/view/1414https://repository.hanyang.ac.kr/handle/20.500.11754/113382
ISSN
0145-5680; 1165-158X
DOI
10.14715/cmb/2017.63.3.6
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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