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design and methods of korean organ transplantation registry

Title
design and methods of korean organ transplantation registry
Author
권오정
Keywords
NEW-ZEALAND DIALYSIS; KIDNEY-TRANSPLANTATION; RECENT PROGRESSES; SURVIVAL BENEFIT; DONATION; RECIPIENTS; AUSTRALIA; OUTCOMES; QUALITY
Issue Date
2017-03
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
TRANSPLANTATION DIRECT, v. 3, no. 8, Article no. e191
Abstract
Background Beneficial aspects of solid organ transplantation, which encompass survival benefit, improved quality of life, and cost efficacy, have been clearly demonstrated. However, regional and ethnic differences require further studies to identify prognostic factors and transplant outcomes against various backgrounds. After previous efforts of a nationwide, retrospective study on the kidney transplant outcomes in Korea, a new prospective-designed version of the Korean Organ Transplantation Registry (KOTRY) was launched in 2014.Methods Cohorts of kidney, liver, heart, lung, and pancreas transplantation were developed. Data on demographics, comorbid conditions, laboratory tests, including tissue typing and panel reactive antibody tests, immunosuppressive regimen followed, concentration and dosage of immunosuppressants, allograft rejection type, infectious events, cardiovascular outcomes, malignancies, donor comorbidity, and outcomes of living donors are collected. Longitudinal data collection is based on a regular annual interval, and blood samples are collected before organ transplantation and again at 1 and 3 years posttransplantation. To enhance data quality, a predefined data verification system operates on a Web-based database, and transplant center users receive regular education about updates. Data are cleansed thrice a year, and feedback given to centers about outlier values and missing data. Annual auditing is conducted.Results Currently, 59 centers are participating in KOTRY. The estimated annual enrollment is more than 2000 cases.Conclusions KOTRY, as a systematic Korean transplant cohort, is expected to provide important information on Asian organ transplantation. The processes used to establish KOTRY provide a good model for launching new nationwide transplant cohort studies.
URI
https://insights.ovid.com/crossref?an=01845228-201708000-00016https://repository.hanyang.ac.kr/handle/20.500.11754/113369
ISSN
2373-8731
DOI
10.1097/TXD.0000000000000678
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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