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dc.contributor.author정민성-
dc.date.accessioned2019-11-21T07:54:01Z-
dc.date.available2019-11-21T07:54:01Z-
dc.date.issued2017-03-
dc.identifier.citationJOURNAL OF KOREAN MEDICAL SCIENCE, v. 32, no. 6, page. 1031-1037en_US
dc.identifier.issn1011-8934-
dc.identifier.issn1598-6357-
dc.identifier.urihttps://jkms.org/DOIx.php?id=10.3346/jkms.2017.32.6.1031-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/113323-
dc.description.abstractThe purpose of this study was to investigate the correlations between tumor-to-background ratio (TBR) obtained from breast-specific gamma imaging (BSGI) and the prognostic factors of breast cancer. Sixty-seven patients with invasive ductal carcinoma who underwent preoperative BSGI were enrolled. The BSGI images were visually scored from 1 to 5 according to a breast imaging reporting and data system (BIRADS). The TBR results obtained from positive BSGI images were compared according to the following prognostic factors: tumor size; axillary lymph node metastasis; nuclear grade (NG); histologic grade (HG); subtype; Ki-67; and the expression profile of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Among 67 images, 60 were classified as a positive finding (sensitivity 89.6%). A higher TBR value was significantly correlated with tumor size >= 2 cm (P= 0.001), axillary lymph node metastasis (P= 0.007), high HG (P= 0.029), negative PR status (P= 0.036), and Ki67 >= 14% (P= 0.007). The TBR showed a significant difference between the luminal A and non-luminal A subtypes (P= 0.007). On multivariate analysis, TBR had a high correlation with tumor size >= 2 cm, axillary lymph node metastasis, and negative PR status (P= 0.003, 0.048, and 0.030, respectively). A high TBR on BSGI was significantly correlated with poor prognostic factors of breast cancer. Luminal A subtype, a breast cancer subtype with more favorable prognosis, was associated with a low TBR on BSGI.en_US
dc.language.isoen_USen_US
dc.publisherKOREAN ACAD MEDICAL SCIENCESen_US
dc.subjectBreast Canceren_US
dc.subjectGamma Camera Imagingen_US
dc.subjectTc-99m-sestaMIBIen_US
dc.titleCorrelations between Tumor to Background Ratio on Breast-Specific Gamma Imaging and Prognostic Factors in Breast Canceren_US
dc.typeArticleen_US
dc.relation.no6-
dc.relation.volume32-
dc.identifier.doi10.3346/jkms.2017.32.6.1031-
dc.relation.page1031-1037-
dc.relation.journalJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.contributor.googleauthorLee, Soo Jin-
dc.contributor.googleauthorChoi, Yun Young-
dc.contributor.googleauthorKim, Chanwoo-
dc.contributor.googleauthorChung, Min Sung-
dc.relation.code2017002851-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidbovie-
dc.identifier.orcidhttp://orcid.org/0000-0001-5086-3718-


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