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Current update of adoptive immunotherapy using cytokine-induced killer cells to eliminate malignant gliomas

Title
Current update of adoptive immunotherapy using cytokine-induced killer cells to eliminate malignant gliomas
Author
한명훈
Keywords
adoptive immunotherapy; clinical trials; cytokine-induced killer (CIK) cells; cytotoxicity; glioma; immune response
Issue Date
2017-03
Publisher
FUTURE MEDICINE LTD
Citation
IMMUNOTHERAPY, v. 9, no. 5, page. 411-421
Abstract
The therapeutic outcome for those with malignant glioma is poor, even though diverse therapeutic modalities have been developed. Immunotherapy has emerged as a therapeutic approach for malignant gliomas, making it possible to selectively treat tumors while sparing normal tissue. Here, we review clinical trials of adoptive immunotherapy approaches for malignant gliomas. We also describe a clinical trial that examined the efficacy and safety of autologous cytokine-induced killer (CIK) cells along with concomitant chemoradiotherapy for newly diagnosed glioblastoma. These CIK cells identify and kill autologous tumor cells. This review focuses on the use of adoptive immunotherapy for malignant gliomas and reviews the current literature on the concept of antitumor activity mediated by CIK cells.
URI
https://www.futuremedicine.com/doi/10.2217/imt-2017-0003https://repository.hanyang.ac.kr/handle/20.500.11754/113086
ISSN
1750-743X; 1750-7448
DOI
10.2217/imt-2017-0003
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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