210 0

Deep gray matter atrophy in neuromyelitis optica spectrum disorder and multiple sclerosis

Title
Deep gray matter atrophy in neuromyelitis optica spectrum disorder and multiple sclerosis
Author
이종민
Keywords
deep gray matter; magnetic resonance imaging; multiple sclerosis; neuromyelitis optica spectrum disorder
Issue Date
2017-02
Publisher
WILEY-BLACKWELL
Citation
EUROPEAN JOURNAL OF NEUROLOGY, v. 24, no. 2, page. 437-445
Abstract
Background and purposeWe investigated changes in deep gray matter (DGM) volume and its relationship to cognition and clinical factors in a large cohort of patients with neuromyelitis optica spectrum disorder (NMOSD) and compared them with results from multiple sclerosis (MS). MethodsBrain magnetic resonance imaging (3 Tesla) and clinical data from 91 patients with NMOSD, 52 patients with MS and 44 healthy controls (HCs) were prospectively evaluated. Differences in DGM volumes were compared among groups. The relationships between DGM atrophy and clinical variables were also analysed. ResultsPatients with NMOSD exhibited significantly reduced thalamic volumes compared with HCs (P = 0.029), although this atrophy was less severe than that seen in patients with MS (P < 0.001). DGM atrophy was restricted to the thalamus in NMOSD, but it was broadly distributed in MS. Patients with NMOSD with cognitive impairment (CI) exhibited more severe thalamic atrophy than those with cognitive preservation (P = 0.017) and HCs (P = 0.003), whereas patients with MS with CI revealed DGM atrophy across the entire structure, with the exception of the bilateral pallidum, left hippocampus and amygdala, relative to HCs. The Expanded Disability Status Scale score was correlated with thalamic atrophy in both NMOSD and MS. Patients with NMOSD with brain lesions demonstrated more severe thalamic atrophy than did those without brain lesions and HCs (P < 0.001). ConclusionsThe DGM atrophy was less severe and more selectively distributed in NMOSD than in MS. Thalamic atrophy was associated with clinical disability, including CI, in both NMOSD and MS.
URI
https://onlinelibrary.wiley.com/doi/abs/10.1111/ene.13224https://repository.hanyang.ac.kr/handle/20.500.11754/112885
ISSN
1351-5101; 1468-1331
DOI
10.1111/ene.13224
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE