Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2019-11-20T21:22:08Z | - |
dc.date.available | 2019-11-20T21:22:08Z | - |
dc.date.issued | 2017-02 | - |
dc.identifier.citation | CELLULAR AND MOLECULAR BIOLOGY, v. 63, no. 1, page. 53-59 | en_US |
dc.identifier.issn | 0145-5680 | - |
dc.identifier.issn | 1165-158X | - |
dc.identifier.uri | https://www.cellmolbiol.org/index.php/CMB/article/view/1140 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/112862 | - |
dc.description.abstract | This study systemically reviewed evidence regarding the relationship between circulating blood transforming growth factor-beta 1 (TGF-beta 1) levels and systemic lupus erythematous (SLE) and rheumatoid arthritis (RA), and associations between TGF-beta 1 polymorphisms and susceptibility to SLE and RA. We conducted a meta-analysis on the serum/plasma TGF-beta 1 levels in SLE and RA patients and healthy controls, and the associations between TGF-beta 1 + 869 T/C, + 915 C/G, and -509 T/C polymorphisms and SLE or RA risk. Twenty-eight studies were considered in this meta-analysis. Circulating TGF-beta 1 levels were significantly lower in the SLE group than in controls (SMD = -1.164, 95% CI = -2.257 --0.070, P = 0.037). Serum/plasma TGF-beta 1 levels were not significantly different between RA and control groups (SMD = 0.699, 95% CI = -0.379 -1.717, p = 0.211). No association between TGF-beta 1 + 869 T/C polymorphism and SLE was found. However, meta-analysis showed an association between the TGF-beta 1 + 869 T allele and RA in all subjects (OR = 1.282, 95% CI = 1.118-1.470, P = 3.8 x 10-4). Analysis after stratification by ethnicity indicated that the T allele was significantly associated with RA in Asians and Arabs (OR = 1.429, 95% CI = 1.179-1.733, P = 2.9 x 10-4; OR = 1.352, 95% CI = 1.097-1.668, P = 0.005), but not Europeans. However, no association was found between TGF-beta 1 + 915 G/C or -509 C/T polymorphisms and RA or SLE. Meta-analysis revealed a significantly lower circulating TGF-beta 1 level in SLE patients, and a significant association between TGF-beta 1 + 869 T/C polymorphism and RA development. | en_US |
dc.description.sponsorship | This study was supported in part by a grant of the Korea Healthcare technology R & D Project, Ministry for Health and Welfare, Republic of Korea (HI15C2958). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | C M B ASSOC | en_US |
dc.subject | TGF-beta 1 | en_US |
dc.subject | level | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | SLE | en_US |
dc.subject | RA | en_US |
dc.title | Association between circulating transforming growth factor-beta 1 level and polymorphisms in systemic lupus erythematosus and rheumatoid arthritis: A meta-analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 63 | - |
dc.identifier.doi | 10.14715/cmb/2017.63.1.11 | - |
dc.relation.page | 53-59 | - |
dc.relation.journal | CELLULAR AND MOLECULAR BIOLOGY | - |
dc.contributor.googleauthor | Lee, Y. H. | - |
dc.contributor.googleauthor | Bae, S-C. | - |
dc.relation.code | 2017001234 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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