Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이연주 | - |
dc.date.accessioned | 2019-11-20T08:14:42Z | - |
dc.date.available | 2019-11-20T08:14:42Z | - |
dc.date.issued | 2017-02 | - |
dc.identifier.citation | NUTRITION RESEARCH AND PRACTICE, v. 11, no. 1, page. 43-50 | en_US |
dc.identifier.issn | 1976-1457 | - |
dc.identifier.issn | 2005-6168 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.4162/nrp.2017.11.6.525 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/112639 | - |
dc.description.abstract | BACKGROUND/OBJECTIVES: The present study investigated the hypothesis that a highly pure linear beta-1,3-glucan produced by Agrobacterium sp. R259 enhances human natural killer (NK) cell activity and suppresses pro-inflammatory cytokines. SUBJECTS/METHODS: In an eight-week, double-blind, randomized, placebo-controlled clinical trial, 83 healthy adults with white blood cell counts of 4,000-8,000 cells/mu L were participated and randomly assigned to take two capsules per day containing either 350 mg 13-1,3-glucan or placebo. Six participants withdrew their study consent or were excluded due to NK cell activity levels outside the normal range. NK cell activity and serum levels of immunoglobulin G (IgG) and cytokines, such as interferon (IFN)-gamma, interleukin (IL)-2, IL-4, IL-6, IL-10, IL-12 and tumor necrosis factor (TNF)-alpha were measured. RESULTS: NK cell activity and the serum levels of IL-10 were significantly higher from baseline to week 8 in the P-glucan group compared with the placebo group (P=0.048, P=0.029). Consumption of beta-1,3-glucan also significantly increased NK cell activity compared with placebo after adjusting for smoking and stress status (P=0.009). In particular, the effect of 13-1,3-glucan on NK cell activity was greater in participants with severe stress than in those experiencing mild stress. However, the administration beta-1,3-glucan did not significantly modulate the levels of IFN-gamma, IL-2, IL-4, IL-6, IL-12, TNF-alpha and IgG compared with the placebo. CONCLUSION: The results showed that supplementation with bacterial beta-1,3-glucan significantly increased NK cell activity without causing any adverse effects. Additionally, the beneficial effect of beta-1,3-glucan on NK cell activity was greater in participants experiencing severe stress. | en_US |
dc.description.sponsorship | This research was supported by the Ministry of Agriculture, Food and Rural Affairs, and partly Korea Food Research Institute and Naturence Co., Ltd. (G0142014039), and by the National Research Foundation of Korea (2015R1D1A1A09060823). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | KOREAN NUTRITION SOC | en_US |
dc.subject | Glucans | en_US |
dc.subject | natural killer cells | en_US |
dc.subject | interleukin-10 | en_US |
dc.subject | cytokines | en_US |
dc.subject | clinical trial | en_US |
dc.title | Agrobacterium sp.-derived beta-1,3-glucan enhances natural killer cell activity in healthy adults: a randomized, double-blind, placebo-controlled, parallel-group study | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 11 | - |
dc.identifier.doi | 10.4162/nrp.2017.11.6.525 | - |
dc.relation.page | 43-50 | - |
dc.relation.journal | NUTRITION RESEARCH AND PRACTICE | - |
dc.contributor.googleauthor | Lee, Yeon Joo | - |
dc.contributor.googleauthor | Paik, Doo-Jin | - |
dc.contributor.googleauthor | Kwon, Dae Young | - |
dc.contributor.googleauthor | Yang, Hye Jeong | - |
dc.contributor.googleauthor | Park, Yongsoon | - |
dc.relation.code | 2017005425 | - |
dc.sector.campus | S | - |
dc.sector.daehak | RESEARCH INSTITUTE[S] | - |
dc.sector.department | KOREAN LIVING SCIENCE RESEARCH INSTITUTE | - |
dc.identifier.pid | yjslee | - |
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