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dc.identifier.citationACTA BIOMATERIALIA, v. 88, Page. 448-461en_US
dc.description.abstractNear-infrared (NIR)-responsive drug delivery systems have enhanced tumor ablative efficiency through permeation and retention effects. Graphene oxide (GO) has shown great potential both in photothermal therapy and in drug delivery. Thus, in this study, we designed an ambient spark-generated GO, wrapped on topotecan (TPT)-loaded hollow mesoporous silica nanoparticles (HMSN-NH2-TPT-CGO), to function as an efficient platform for pH-dependent sustained release of TPT. HMSN-NH2-TPT-CGO also exhibited a combined chemo-photothermal effect within a single carrier system. This developed system was stable with a uniform particle size (similar to 190 nm) and was demonstrated to possess a sufficient heat-absorbing capacity to induce tumor cell ablation. We performed the ablation of tumor cells both in vitro and in vivo in combination with photothermal therapy and chemotherapy using the spark-generated functional GO and HMSN. The prepared nanocarriers demonstrated high cellular uptake, apoptosis, and G0/G1 cell cycle arrest. In vivo study using the MDA-MB-231 xenograft model revealed the ultraefficient tumor ablative performance of HMSN-NH2-TPT-CGO compared with that of free TPT, with no toxic effect on vital organs. Altogether, the optimized nanocarriers presented a significant potential to act as a vehicle for cancer treatment. Statement of Significance This is the first study that uses spark-generated graphene oxide nanoflakes to cover the topotecan (TPT)-loaded hollow mesoporous silica nanoparticles (HMSNs) to treat breast cancer. Dense silica was used as a hard template to prepare the HMSNs attributing to a high drug payload. The concentration of Na2CO3 was precisely controlled to minimize the silica etching time within 70 min. The use of the nanographene flakes served a dual purpose, first, by acting as a capping agent to prevent the premature release of drug and, second, by serving as a nano heater that significantly ablates the tumor cells. The prepared nanocarriers (NCs) exhibited effective and enhanced in vitro and in vivo apoptosis, as well as significant tumor growth inhibition even after 15 days of treatment time, with no toxic effect to the vital organs. The NCs enhanced in vitro tumor cell killing effects and served as an effective carrier for in vivo tumor regression, thereby highlighting the enormous potential of this system for breast cancer therapy. (C) 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipThis research was supported by National Research Foundation of Korea (NRF) grants funded by the Korean Government (MSIP) (No. 2018R1A2A2A05021143) and by the Medical Research Center Program (2015R1A5A2009124, 2018R1A5A2025272) through the NRF funded by MSIP. This research was also supported by a grant (16173MFDS542) from the Ministry of Food and Drug Safety 2016.en_US
dc.publisherELSEVIER SCI LTDen_US
dc.subjectGraphene oxideen_US
dc.subjectHollow mesoporous silica nanoparticlesen_US
dc.subjectPhotothermal therapyen_US
dc.titleAerosol technique-based carbon-encapsulated hollow mesoporous silica nanoparticles for synergistic chemo-photothermal therapyen_US
dc.relation.journalACTA BIOMATERIALIA-
dc.contributor.googleauthorGautam, Milan-
dc.contributor.googleauthorThapa, Raj Kumar-
dc.contributor.googleauthorPoudel, Bijay Kumar-
dc.contributor.googleauthorGupta, Biki-
dc.contributor.googleauthorRuttala, Hima Bindu-
dc.contributor.googleauthorNguyen, Hanh Thuy-
dc.contributor.googleauthorSoe, Zar Chi-
dc.contributor.googleauthorOu, Wenquan-
dc.contributor.googleauthorPoudel, Kishwor-
dc.contributor.googleauthorChoi, Han-Gon-
dc.contributor.googleauthorKu, Sae Kwang-
dc.contributor.googleauthorYong, Chul Soon-
dc.contributor.googleauthorKim, Jong Oh-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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