Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 문진화 | - |
dc.date.accessioned | 2019-11-19T06:04:48Z | - |
dc.date.available | 2019-11-19T06:04:48Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.citation | PEDIATRIC NEUROLOGY, v. 66, page. 96-99 | en_US |
dc.identifier.issn | 0887-8994 | - |
dc.identifier.issn | 1873-5150 | - |
dc.identifier.uri | https://www.pedneur.com/article/S0887-8994(16)30222-3/fulltext | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/112337 | - |
dc.description.abstract | BACKGROUND: Transient bulbar palsy without involvement of the facial or extraocular muscles is a rare presentation. It is considered a form of cranial polyneuropathy, a variant of Guillain Barre syndrome that is related to the autoimmune mechanisms induced by preceding infections or vaccinations. However, drug-induced cranial polyneuropathy has not previously been reported. We describe a boy with isolated bulbar palsy and positive serum antiganglioside antibodies during aripiprazole treatment. PATIENT DESCRIPTION: This 12-year-old boy was admitted with a seven-day history of dysarthria, tongue discomfort, and tinnitus. Three weeks before symptom onset, aripiprazole was added to the patient's medications for attention-deficit hyperactivity disorder. On examination, he showed curtaining of the pharyngeal wall, tongue fasciculation and deviation, and a weak gag reflex. Cranial magnetic resonance imaging suggested lower cranial nerve involvement. Serum anti-GM1 IgG and anti-GD1b IgG antibodies were positive. After stopping aripiprazole, his bulbar symptoms improved. However, on readministration of aripiprazole seven weeks later, dysarthria recurred and again resolved after stopping the drug. CONCLUSION: We describe the first patient with anti-GM1 IgG and anti-GD1b IgG antibodies associated transient cranial polyneuropathy presenting as isolated bulbar palsy. These findings could be an adverse effect of aripiprazole treatment. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE INC | en_US |
dc.subject | bulbar palsy | en_US |
dc.subject | cranial polyneuropathy | en_US |
dc.subject | polyneuritis cranialis | en_US |
dc.subject | antiganglioside antibody | en_US |
dc.subject | aripiprazole | en_US |
dc.subject | anti-GM1 antibody | en_US |
dc.subject | anti-GD1b antibody | en_US |
dc.title | Transient Isolated Lower Bulbar Palsy With Elevated Serum Anti-GM1 and Anti-GD1b Antibodies During Aripiprazole Treatment | en_US |
dc.type | Article | en_US |
dc.relation.volume | 66 | - |
dc.identifier.doi | 10.1016/j.pediatrneurol.2016.07.011 | - |
dc.relation.page | 96-99 | - |
dc.relation.journal | PEDIATRIC NEUROLOGY | - |
dc.contributor.googleauthor | Han, Tae Hwan | - |
dc.contributor.googleauthor | Kim, Do Yeon | - |
dc.contributor.googleauthor | Park, Dong Woo | - |
dc.contributor.googleauthor | Moon, Jin-Hwa | - |
dc.relation.code | 2017003142 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jinhwamoon | - |
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