Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2019-11-19T06:02:59Z | - |
dc.date.available | 2019-11-19T06:02:59Z | - |
dc.date.issued | 2019-02 | - |
dc.identifier.citation | PHARMACEUTICS, v. 11, No. 2, Article no. 63 | en_US |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.uri | https://www.mdpi.com/1999-4923/11/2/63 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/112333 | - |
dc.description.abstract | In this study, a transferrin (T-f)-conjugated polymeric nanoparticle was developed for the targeted delivery of the chemotherapeutic agent doxorubicin (Dox) in order to overcome multi-drug resistance in cancer treatment. Our objective was to improve Dox delivery for producing significant antitumor efficacy in Dox-resistant (R) breast cancer cell lines with minimum toxicity to healthy cells. The results of our experiments revealed that Dox was successfully loaded inside a transferrin (T-f)-conjugated polymeric nanoparticle composed of poloxamer 407 (F127) and 123 (P123) (Dox/F127&P123-T-f), which produced nanosized particles (similar to 90 nm) with a low polydispersity index (similar to 0.23). The accelerated and controlled release profiles of Dox from the nanoparticles were characterized in acidic and physiological pH and Dox/F127&P123-T-f enhanced Dox cytotoxicity in OVCAR-3, MDA-MB-231, and MDA-MB-231(R) cell lines through induction of cellular apoptosis. Moreover, Dox/F127&P123-T-f inhibited cell migration and altered the cell cycle patterns of different cancer cells. In vivo study in MDA-MB-231(R) tumor-bearing mice demonstrated enhanced delivery of nanoparticles to the tumor site when coated in a targeting moiety. Therefore, Dox/F127&P123-T-f has been tailored, using the principles of nanotherapeutics, to overcome drug-resistant chemotherapy. | en_US |
dc.description.sponsorship | This research was supported by a National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2018R1A2A2A05021143), and by the Medical Research Center Program (2018R1A5A2025272) through the NRF, funded by MSIP. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | MDPI | en_US |
dc.subject | doxorubicin | en_US |
dc.subject | doxorubicin-resistant cancer | en_US |
dc.subject | polymeric nanoparticles | en_US |
dc.subject | transferrin | en_US |
dc.title | Transferrin-Conjugated Polymeric Nanoparticle for Receptor-Mediated Delivery of Doxorubicin in Doxorubicin-Resistant Breast Cancer Cells | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 11 | - |
dc.identifier.doi | 10.3390/pharmaceutics11020063 | - |
dc.relation.page | 63-80 | - |
dc.relation.journal | PHARMACEUTICS | - |
dc.contributor.googleauthor | Soe, Zar Chi | - |
dc.contributor.googleauthor | Kwon, Jun Bum | - |
dc.contributor.googleauthor | Thapa, Raj Kumar | - |
dc.contributor.googleauthor | Ou, Wenquan | - |
dc.contributor.googleauthor | Nguyen, Hanh Thuy | - |
dc.contributor.googleauthor | Gautam, Milan | - |
dc.contributor.googleauthor | Oh, Kyung Taek | - |
dc.contributor.googleauthor | Choi, Han-Gon | - |
dc.contributor.googleauthor | Ku, Sae Kwang | - |
dc.contributor.googleauthor | Yong, Chul Soon | - |
dc.contributor.googleauthor | Kim, Jong Oh | - |
dc.relation.code | 2019045021 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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