Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신흥수 | - |
dc.date.accessioned | 2019-11-19T05:54:52Z | - |
dc.date.available | 2019-11-19T05:54:52Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.citation | JOURNAL OF MATERIALS CHEMISTRY B, v. 5, no. 2, page. 318-328 | en_US |
dc.identifier.issn | 2050-750X | - |
dc.identifier.issn | 2050-7518 | - |
dc.identifier.uri | https://pubs.rsc.org/en/content/articlelanding/2017/TB/C6TB02258H#!divAbstract | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/112329 | - |
dc.description.abstract | A monolayer of endothelial cells (ECs) aligned along the direction of blood flow plays crucial roles in the regulation of anti-thrombogenic and pro-inflammatory reactions in the blood vessel wall. Thus, many researchers have attempted to mimic the aligned structure of ECs in vascular grafts or tissue-engineered blood vessels. In the present study, we fabricated micro-groove patterned nanofibers using a femtosecond laser ablation technique to recapitulate the densely organized anisotropic architecture of the endothelial layer. Femtosecond laser ablation enabled us to generate high-resolution groove patterns (10 mm width) with 20 or 80 mm gaps on randomly oriented electrospun nanofibers. The patterned nanofibers exhibited anisotropic (transverse: 101.1 +/- 4.0 degrees and longitudinal: 123.5 +/- 9.4 degrees) water contact angles; however, the mechanical properties were consistent in both directions. The micropatterned nanofibers modulated the aligned structure or aspect ratio (20 mm: 0.23 +/- 0.11 and 80 mm: 0.42 +/- 0.18) of ECs along the pattern direction. In particular, the engineered aligned endothelial layer was effective in eliciting an anti-inflammatory response (approximately 50% greater than that of random or aligned nanofibers), thereby effectively preventing monocyte adhesion following activation by TNF-alpha treatment. Therefore, micropatterning by laser ablation can be utilized to generate high-resolution microgrooves on various substrates, thereby providing fundamental platforms for vascular tissue engineering. | en_US |
dc.description.sponsorship | This work was supported by the Radiation Technology R&D program and Basic Research Program through the National Research Foundation of Korea (NRF) grants funded by the Ministry of Science, ICT, & Future Planning (NRF-2016M2A2A6021739 and NRF-2016R1A2B3009936), and the KIST project (2V04910). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ROYAL SOC CHEMISTRY | en_US |
dc.subject | CORONARY-ARTERY-DISEASE | en_US |
dc.subject | SHEAR-STRESS | en_US |
dc.subject | TISSUE SCAFFOLDS | en_US |
dc.subject | STEM-CELLS | en_US |
dc.subject | ORGANIZATION | en_US |
dc.subject | TOPOGRAPHIES | en_US |
dc.subject | MIGRATION | en_US |
dc.subject | PROPERTY | en_US |
dc.subject | PATTERNS | en_US |
dc.subject | MYOTUBES | en_US |
dc.title | Engineering an aligned endothelial monolayer on a topologically modified nanofibrous platform with a micropatterned structure produced by femtosecond laser ablation | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 5 | - |
dc.identifier.doi | 10.1039/c6tb02258h | - |
dc.relation.page | 318-328 | - |
dc.relation.journal | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.contributor.googleauthor | Shin, Young Min | - |
dc.contributor.googleauthor | Shin, Hyeok Jun | - |
dc.contributor.googleauthor | Heo, Yunhoe | - |
dc.contributor.googleauthor | Jun, Indong | - |
dc.contributor.googleauthor | Chung, Yong-Woo | - |
dc.contributor.googleauthor | Kim, Kyeongsoo | - |
dc.contributor.googleauthor | Lim, Youn Mook | - |
dc.contributor.googleauthor | Jeon, Hojeong | - |
dc.contributor.googleauthor | Shin, Heungsoo | - |
dc.relation.code | 2017002432 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | hshin | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.