Tumor-associated mesenchymal stem-like cells provide extracellular signaling cue for invasiveness of glioblastoma cells
- Title
- Tumor-associated mesenchymal stem-like cells provide extracellular signaling cue for invasiveness of glioblastoma cells
- Author
- 이수재
- Keywords
- extracellular matrix remodeling; mesenchymal stem-like cells; hyaluronic acid; hyaluronic acid synthase-2; C5a
- Issue Date
- 2017-01
- Publisher
- IMPACT JOURNALS LLC
- Citation
- ONCOTARGET, v. 8, no. 1, page. 1438-1448
- Abstract
- Hyaluronic acid (HA) is abundant in tumor microenvironment and closely associated with invasiveness of glioblastoma (GM) cells. However, the cellular mechanism underlying HA-rich microenvironment in GBM remains unexplored. Here, we show that tumor-associated mesenchymal stem-like cells (tMSLCs) contribute to abundance of hyaluronic acid (HA) in tumor microenvironment through HA synthase-2 (HAS2) induction, and thereby enhances invasiveness of GBM cells. In an autocrine manner, C5a secreted by tMSLCs activated ERK MAPK for HAS2 induction in tMSLCs. Importantly, HA acted as a signaling ligand of its cognate receptor RHAMM for intracellular signaling activation underlying invasiveness of GBM cells. Taken together, our study suggests that tMSLCs contribute to HA-rich proinvasive ECM microenvironment in GBM.
- URI
- http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=13638&path[]=43320https://repository.hanyang.ac.kr/handle/20.500.11754/112309
- ISSN
- 1949-2553
- DOI
- 10.18632/oncotarget.13638
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML