Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김안모 | - |
dc.date.accessioned | 2019-11-19T05:27:06Z | - |
dc.date.available | 2019-11-19T05:27:06Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.citation | CELL, v. 168, no. 1-2, page. 280-294 | en_US |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.issn | 1097-4172 | - |
dc.identifier.uri | https://www.cell.com/cell/fulltext/S0092-8674(16)31679-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867416316798%3Fshowall%3Dtrue | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/112283 | - |
dc.description.abstract | Vision influences behavior, but ongoing behavior also modulates vision in animals ranging from insects to primates. The function and biophysical mechanisms of most such modulations remain unresolved. Here, we combine behavioral genetics, electrophysiology, and high-speed videography to advance a function for behavioral modulations of visual processing in Drosophila. We argue that a set of motion-sensitive visual neurons regulate gaze-stabilizing head movements. We describe how, during flight turns, Drosophila perform a set of head movements that require silencing their gaze-stability reflexes along the primary rotation axis of the turn. Consistent with this behavioral requirement, we find pervasive motor-related inputs to the visual neurons, which quantitatively silence their predicted visual responses to rotations around the relevant axis while preserving sensitivity around other axes. This work proposes a function for a behavioral modulation of visual processing and illustrates how the brain can remove one sensory signal from a circuit carrying multiple related signals. | en_US |
dc.description.sponsorship | We thank members of the G.M. lab and Vanessa Ruta for comments on the manuscript. Peter Weir provided code that helped to generate the starfield stimuli. Atsuko Adachi and Jonathan Hirokawa helped imaging and registering Kir2.1-expressing brains. Molly Liu set up the magnetic tether assay. Farid Aboharb and Itzel Ishida conducted preliminary experiments on the magnetic tether apparatus. Aditya Nair conducted preliminary tethered-flight experiments. Meishel DeSouto drew the fly in the graphical abstract. We thank Karin Panser and Andrew Straw for the gift of the +;tsh-GAL80;VT058487-GAL4 recombined line and insightful discussions. We obtained fly stocks from the Bloomington Drosophila Stock Center (NIH P40OD018537) and the Vienna Drosophila Resource Center. L.M.F. was supported by funds from a Leon Levy Fellowship in Mind, Brain, and Behavior at The Rockefeller University (CEN5301162). This work was supported by the New York Stem Cell Foundation (NYSCF-R-NI13), Searle Scholars Foundation (12-SSP-153), and the National Institute on Drug Abuse of the NIH (DP2DA035148). G.M. is a New York Stem Cell Foundation-Robertson Investigator. | en_US |
dc.language.iso | en | en_US |
dc.publisher | CELL PRESS | en_US |
dc.subject | Drosophila | en_US |
dc.subject | vision | en_US |
dc.subject | visuomotor processing | en_US |
dc.subject | electrophysiology | en_US |
dc.subject | patch-clamp | en_US |
dc.subject | eye movements | en_US |
dc.subject | efference copy | en_US |
dc.subject | corollary discharge | en_US |
dc.subject | action initiation | en_US |
dc.subject | neural circuits | en_US |
dc.title | Quantitative Predictions Orchestrate Visual Signaling in Drosophila | en_US |
dc.type | Article | en_US |
dc.relation.no | 1-2 | - |
dc.relation.volume | 168 | - |
dc.identifier.doi | 10.1016/j.cell.2016.12.005 | - |
dc.relation.page | 280-280 | - |
dc.relation.journal | CELL | - |
dc.contributor.googleauthor | Kim, Anmo J. | - |
dc.contributor.googleauthor | Fenk, Lisa M. | - |
dc.contributor.googleauthor | Lyu, Cheng | - |
dc.contributor.googleauthor | Maimon, Gaby | - |
dc.relation.code | 2017002172 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING | - |
dc.identifier.pid | anmokim | - |
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