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Rational combination immunotherapeutic approaches for effective cancer treatment

Title
Rational combination immunotherapeutic approaches for effective cancer treatment
Author
최한곤
Keywords
Cancer; Combination; Immunotherapy
Issue Date
2019-01
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF CONTROLLED RELEASE, v. 294, Page. 114-130
Abstract
Immunotherapy is an important mode of cancer treatment. Over the past decades, immunotherapy has improved the clinical outcome for cancer patients. However, in many cases, mutations in cancer cells, lack of selectivity, insufficiency of tumor-reactive T cells, and host immunosuppression limit the clinical benefit of immunotherapy. Combination approaches in immunotherapy may overcome these obstacles. Accumulating evidence demonstrates that combination immunotherapy is the future of cancer treatment. However, designing safe and rational combinations of immunotherapy with other treatment modalities is critical. This review will discuss the optimal immunotherapy-based combinations mainly with respect to the mechanisms of action of individual therapeutic agents that target multiple steps in evasion and progression of tumor.
URI
https://www.sciencedirect.com/science/article/pii/S0168365918307235https://repository.hanyang.ac.kr/handle/20.500.11754/112176
ISSN
0168-3659; 1873-4995
DOI
10.1016/j.jconrel.2018.12.020
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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