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dc.contributor.author최한곤-
dc.date.accessioned2019-11-18T04:45:53Z-
dc.date.available2019-11-18T04:45:53Z-
dc.date.issued2019-01-
dc.identifier.citationASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, v. 14, No. 1, Page. 40-51en_US
dc.identifier.issn1818-0876-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1818087618308420-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/112151-
dc.description.abstractFolate-targeting self-assembled nanoparticles (NPs) using biocompatible and biodegradable natural polymers chitosan (Cs) and chondroitin sulfate (Chs) were developed to address the major challenge in cancer treatment, the selective delivery of nanoparticles to the target site. In this study, we successfully incorporated a hydrophobic drug, bortezomib (Bor), into folic acid (FA)-conjugated Cs/Chs self-assembled NPs (Bor/Cs/Chs-FA) for colorectal cancer therapy. The particle size and polydispersity index of Bor/Cs/Chs-FA were similar to 196.5 +/- 1.2 nm and similar to 0.21 +/- 0.5, respectively. A pH-dependent release profile was observed, facilitating cancer cell-targeted drug release under an acidic tumor microenvironment. Moreover, in vitro data revealed enhanced cellular uptake and apoptosis in folate receptor-expressing colorectal cancer cells (HCT-116 and HT-29) as compared to that in lung cancer cells (A549), which do not express folate receptors. Furthermore, intravenous administration of Bor/Cs/Chs-FA in a HCT-116 bearing xenograft mouse model showed that the NPs were a safe and effective drug delivery system. The results suggest that folate-targeted nanoparticle can be effectively applied for efficient chemotherapy of colorectal cancer.en_US
dc.description.sponsorshipThis research was supported by the Yeungnam University research grant in 2017.en_US
dc.language.isoen_USen_US
dc.publisherSHENYANG PHARMACEUTICAL UNIVen_US
dc.subjectBortezomiben_US
dc.subjectChitosan chondroitin sulfateen_US
dc.subjectColorectal canceren_US
dc.subjectFolic aciden_US
dc.titleFolate-targeted nanostructured chitosan/chondroitin sulfate complex carriers for enhanced delivery of bortezomib to colorectal cancer cellsen_US
dc.typeArticleen_US
dc.relation.no1-
dc.relation.volume14-
dc.identifier.doi10.1016/j.ajps.2018.09.004-
dc.relation.page40-51-
dc.relation.journalASIAN JOURNAL OF PHARMACEUTICAL SCIENCES-
dc.contributor.googleauthorSoe, Zar Chi-
dc.contributor.googleauthorPoudel, Bijay Kumar-
dc.contributor.googleauthorNguyen, Hanh Thuy-
dc.contributor.googleauthorThapa, Raj Kumar-
dc.contributor.googleauthorOu, Wenquan-
dc.contributor.googleauthorGautam, Milan-
dc.contributor.googleauthorPoudel, Kishwor-
dc.contributor.googleauthorJin, Sung Giu-
dc.contributor.googleauthorJeong, Jee-Heon-
dc.contributor.googleauthorKu, Sae Kwang-
dc.contributor.googleauthorChoi, Han-Gon-
dc.contributor.googleauthorYong, Chul Soon-
dc.contributor.googleauthorKim, Jong Oh-
dc.relation.code2019044776-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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