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Folate-targeted nanostructured chitosan/chondroitin sulfate complex carriers for enhanced delivery of bortezomib to colorectal cancer cells

Title
Folate-targeted nanostructured chitosan/chondroitin sulfate complex carriers for enhanced delivery of bortezomib to colorectal cancer cells
Author
최한곤
Keywords
Bortezomib; Chitosan chondroitin sulfate; Colorectal cancer; Folic acid
Issue Date
2019-01
Publisher
SHENYANG PHARMACEUTICAL UNIV
Citation
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, v. 14, No. 1, Page. 40-51
Abstract
Folate-targeting self-assembled nanoparticles (NPs) using biocompatible and biodegradable natural polymers chitosan (Cs) and chondroitin sulfate (Chs) were developed to address the major challenge in cancer treatment, the selective delivery of nanoparticles to the target site. In this study, we successfully incorporated a hydrophobic drug, bortezomib (Bor), into folic acid (FA)-conjugated Cs/Chs self-assembled NPs (Bor/Cs/Chs-FA) for colorectal cancer therapy. The particle size and polydispersity index of Bor/Cs/Chs-FA were similar to 196.5 +/- 1.2 nm and similar to 0.21 +/- 0.5, respectively. A pH-dependent release profile was observed, facilitating cancer cell-targeted drug release under an acidic tumor microenvironment. Moreover, in vitro data revealed enhanced cellular uptake and apoptosis in folate receptor-expressing colorectal cancer cells (HCT-116 and HT-29) as compared to that in lung cancer cells (A549), which do not express folate receptors. Furthermore, intravenous administration of Bor/Cs/Chs-FA in a HCT-116 bearing xenograft mouse model showed that the NPs were a safe and effective drug delivery system. The results suggest that folate-targeted nanoparticle can be effectively applied for efficient chemotherapy of colorectal cancer.
URI
https://www.sciencedirect.com/science/article/pii/S1818087618308420https://repository.hanyang.ac.kr/handle/20.500.11754/112151
ISSN
1818-0876
DOI
10.1016/j.ajps.2018.09.004
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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