Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이춘근 | - |
dc.date.accessioned | 2019-11-07T05:01:17Z | - |
dc.date.available | 2019-11-07T05:01:17Z | - |
dc.date.issued | 2019-05 | - |
dc.identifier.citation | YONSEI MEDICAL JOURNAL, v. 60, NO 5, Page. 407-413 | en_US |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.issn | 1976-2437 | - |
dc.identifier.uri | https://eymj.org/DOIx.php?id=10.3349/ymj.2019.60.5.407 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/111962 | - |
dc.description.abstract | Although chronic obstructive pulmonary disease (COPD) is regarded as a chronic inflammatory lung disease, the disease mechanism is still not known. Intriguingly, aging lungs are quite similar to COPD-affected lungs in many ways, and COPD has been viewed as a disease of accelerated premature aging of the lungs. In this paper, based on a literature review, we would like to propose immunosenescence, age-associated decline in immunity, as a critical mechanism for the development of COPD. Immunosenescence can cause a low-grade, systemic inflammation described as inflammaging. This inflammaging may be directly involved in the COPD pathogenesis. The potential contributors to the development of inflammaging in the lungs possibly leading to COPD are discussed in the review paper. A notable fact about COPD is that only 15% to 20% of smokers develop clinically significant COPD. Given that there is a substantial inter-individual variation in inflammaging susceptibility, which is genetically determined and significantly affected by the history of the individual's exposure to pathogens, immunosenescence and inflammaging may also provide the answer for this unexpectedly low susceptibility of smokers to clinically significant COPD. | en_US |
dc.description.sponsorship | This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education (NRF-2016 R1D1A1B01015292 to L.K.K.). | en_US |
dc.language.iso | en | en_US |
dc.publisher | YONSEI UNIV COLL MEDICINE | en_US |
dc.subject | COPD | en_US |
dc.subject | immunosenescence | en_US |
dc.subject | inflammaging | en_US |
dc.subject | inflammation | en_US |
dc.subject | aging | en_US |
dc.title | COPD as a Disease of Immunosenescence | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 60 | - |
dc.identifier.doi | 10.3349/ymj.2019.60.5.407 | - |
dc.relation.page | 407-413 | - |
dc.relation.journal | YONSEI MEDICAL JOURNAL | - |
dc.contributor.googleauthor | Cho, Won-Kyung | - |
dc.contributor.googleauthor | Lee, Chun Geun | - |
dc.contributor.googleauthor | Kim, Lark Kyun | - |
dc.relation.code | 2019000339 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | brownchun | - |
dc.identifier.orcid | http://orcid.org/0000-0002-9514-3658 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.