Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이창범 | - |
dc.date.accessioned | 2019-11-04T07:32:13Z | - |
dc.date.available | 2019-11-04T07:32:13Z | - |
dc.date.issued | 2019-08 | - |
dc.identifier.citation | DIABETES THERAPY, v. 10, NO 4, Page. 1271-1282 | en_US |
dc.identifier.issn | 1869-6953 | - |
dc.identifier.issn | 1869-6961 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs13300-019-0628-0 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/111807 | - |
dc.description.abstract | Introduction Teneligliptin, an antidiabetic agent classified as a class III dipeptidyl peptidase-4 (DPP-4) inhibitor, has a unique structural feature that provides strong binding to DPP-4 enzymes. We investigated the efficacy and safety of switching patients with type 2 diabetes mellitus (T2DM) who had inadequate glycemic control on a stable dose of other DPP-4 inhibitors to teneligliptin.Methods Patients with T2DM whose glycosylated hemoglobin (HbA1c) levels were >= 7% despite taking DPP-4 inhibitors other than teneligliptin, with or without other hypoglycemic agents, for at least 3months were enrolled. The DPP-4 inhibitors taken before participating in the study were switched to 20mg qd teneligliptin, and this was to be maintained for 52weeks. The primary end point was the change in HbA1c levels after 12weeks. Metabolic parameters including fasting plasma glucose (FPG) and blood lipids were assessed also. To assess safety, adverse and hypoglycemic events were monitored. The data from baseline to week 12 were used for analysis in this interim report.Results The mean change in HbA1c levels from baseline to week 12 was - 0.44%. At week 12, the percentage of patients achieving HbA1c<7.0% was 31.6% and that of achieving HbA1c<6.5% was 11.4%, respectively. In 41.2% of patients, the HbA1c levels decreased by at least 0.5% at 12weeks. The mean change in FPG levels from baseline to week 12 was - 11.5mg/dl. No severe hypoglycemia was reported. Conclusion After switching to teneligliptin, HbA1c levels decreased significantly in patients with T2DM inadequately controlled with other DPP-4 inhibitors.Trial RegistrationClinicalTrials.gov, NCT03793023.FundingHandok Inc. | en_US |
dc.description.sponsorship | Sponsorship for this study and article processing charges were funded by the Handok Inc., Seoul, Republic of Korea. All authors had full access to all of the data in this study and take complete responsibility for the integrity of the data and accuracy of the data analysis. | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPRINGER HEIDELBERG | en_US |
dc.subject | Diabetes mellitus | en_US |
dc.subject | Type 2 | en_US |
dc.subject | Dipeptidyl-peptidase IV inhibitors | en_US |
dc.subject | Teneligliptin | en_US |
dc.title | Efficacy and Safety of Switching to Teneligliptin in Patients with Type 2 Diabetes Inadequately Controlled with Dipeptidyl Peptidase-4 Inhibitors: A 12-Week Interim Report | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 10 | - |
dc.identifier.doi | 10.1007/s13300-019-0628-0 | - |
dc.relation.page | 1-10 | - |
dc.relation.journal | DIABETES THERAPY | - |
dc.contributor.googleauthor | Kim, Hae Jin | - |
dc.contributor.googleauthor | Kim, Young Sik | - |
dc.contributor.googleauthor | Lee, Chang Beom | - |
dc.contributor.googleauthor | Choi, Moon-Gi | - |
dc.contributor.googleauthor | Chang, Hyuk-Jae | - |
dc.contributor.googleauthor | Kim, Soo Kyoung | - |
dc.contributor.googleauthor | Yu, Jae Myung | - |
dc.contributor.googleauthor | Kim, Tae Ho | - |
dc.contributor.googleauthor | Lee, Ji Hyun | - |
dc.contributor.googleauthor | Ahn, Kyu Jeung | - |
dc.relation.code | 2019036311 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | lekang | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.