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dc.contributor.author배상철-
dc.date.accessioned2019-11-04T07:09:39Z-
dc.date.available2019-11-04T07:09:39Z-
dc.date.issued2019-05-
dc.identifier.citationLUPUS, v. 28, NO 6, Page. 740-747en_US
dc.identifier.issn0961-2033-
dc.identifier.issn1477-0962-
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/0961203319844014-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/111804-
dc.description.abstractObjective The aim of this study is to determine whether the functional interferon regulatory factor 5 (IRF5) polymorphism rs2004640 is associated with susceptibility to systemic lupus erythematosus (SLE) in multiple ethnic populations. Methods A meta-analysis was conducted on the T allele of the IRF5 rs2004640 polymorphism in all study participants as well as each ethnic population. Results Twenty research articles that included 28 comparative studies of 20,892 patients and 24,930 controls were included in the meta-analysis. The Asian population had a much lower prevalence of the T allele than any other study population at 28%, and the European population had the highest prevalence of the T allele at 52%. Meta-analysis showed an association between the IRF5 rs2004640 polymorphism and SLE in all participants (odds ratio=1.472, 95% confidence interval=1.370-1.582, p˂0.001). Analysis after stratification by ethnicity indicated that the IRF5 rs2004640T allele is significantly associated with SLE in Europeans, Asians, Latin Americans and Arabs. Conclusions This meta-analysis confirms that the IRF5 rs2004640 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.en_US
dc.description.sponsorshipThe authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported in part by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT (NRF-2017M3A9B4050335), Republic of Korea.en_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.subjectIRF5en_US
dc.subjectmeta-analysisen_US
dc.subjectpolymorphismen_US
dc.subjectsystemic lupus erythematosusen_US
dc.titleAssociation between the interferon regulatory factor 5 rs2004640 functional polymorphism and systemic lupus erythematosus: an updated meta-analysisen_US
dc.typeArticleen_US
dc.relation.no6-
dc.relation.volume28-
dc.identifier.doi10.1177/0961203319844014-
dc.relation.page740-747-
dc.relation.journalLUPUS-
dc.contributor.googleauthorBae, S. C.-
dc.contributor.googleauthorLee, Y. H.-
dc.relation.code2019003216-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidscbae-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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