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dc.contributor.author장일훈-
dc.date.accessioned2019-10-31T02:10:42Z-
dc.date.available2019-10-31T02:10:42Z-
dc.date.issued2019-04-
dc.identifier.citationANALYTICAL CHEMISTRY, v. 91, NO 7, Page. 4868-4875en_US
dc.identifier.issn0003-2700-
dc.identifier.issn1520-6882-
dc.identifier.urihttps://pubs.acs.org/doi/10.1021/acs.analchem.9b00624-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/111685-
dc.description.abstractThe viscosity of biofluids can be used to acquire meaningful medical information on the conditions of a patient but has seldom been utilized in clinical practices owing to cumbersome measurement procedures and the need for large sample volumes. We present a colorimetric method to measure the viscosity of blood plasma using a paper-based viscometer developed in this study specifically for clinical diagnosis. The proposed analytical device consists of multilayered papers with fluid-loading, -mixing, and -measuring regions, and it can be fabricated readily in a simple manner using three-layered paper channels and tape. Moreover, the colorimetric analysis enables viscosity estimations by analyzing a single optical image. To validate the device performance, we measured the viscosities of fluids such as glycerin aqueous solutions, bovine-serum-albumin solution, dimethyl sulfoxide, and blood plasma. We found that the measured viscosities were in good agreement with the reference values. Finally, we developed a simple smartphone application for the viscosity measurements that helped enhance the convenience and utility of the paper-based viscometer while maintaining the measurement accuracy.en_US
dc.description.sponsorshipThis work was financially supported by a National Research Foundation of Korea (NRF) grant funded by the Korea government (Nos. 2012R1A6A1029029, 2016R1A2B3009541, and 2018R1A6A3A11043917).en_US
dc.language.isoenen_US
dc.publisherAMER CHEMICAL SOCen_US
dc.subjectMICROFLUIDIC VISCOMETERen_US
dc.subjectANALYTICAL DEVICEen_US
dc.subjectSURFACE-TENSIONen_US
dc.subjectVISCOSITYen_US
dc.subjectFLOWen_US
dc.subjectPOINTen_US
dc.subjectCONSTITUENTSen_US
dc.subjectDYNAMICSen_US
dc.subjectCHANNELen_US
dc.subjectSERUMen_US
dc.titleDevelopment of a Paper-Based Viscometer for Blood Plasma Using Colorimetric Analysisen_US
dc.typeArticleen_US
dc.relation.no7-
dc.relation.volume91-
dc.identifier.doi10.1021/acs.analchem.9b00624-
dc.relation.page4868-4875-
dc.relation.journalANALYTICAL CHEMISTRY-
dc.contributor.googleauthorKang, Hyunwoong-
dc.contributor.googleauthorJang, Ilhoon-
dc.contributor.googleauthorSong, Simon-
dc.contributor.googleauthorBae, Sang-Cheol-
dc.relation.code2019001589-
dc.sector.campusS-
dc.sector.daehakRESEARCH INSTITUTE[S]-
dc.sector.departmentINSTITUTE OF NANO SCIENCE AND TECHNOLOGY-
dc.identifier.pidiroonjang-
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