83 0

Development of a Paper-Based Viscometer for Blood Plasma Using Colorimetric Analysis

Title
Development of a Paper-Based Viscometer for Blood Plasma Using Colorimetric Analysis
Author
장일훈
Keywords
MICROFLUIDIC VISCOMETER; ANALYTICAL DEVICE; SURFACE-TENSION; VISCOSITY; FLOW; POINT; CONSTITUENTS; DYNAMICS; CHANNEL; SERUM
Issue Date
2019-04
Publisher
AMER CHEMICAL SOC
Citation
ANALYTICAL CHEMISTRY, v. 91, NO 7, Page. 4868-4875
Abstract
The viscosity of biofluids can be used to acquire meaningful medical information on the conditions of a patient but has seldom been utilized in clinical practices owing to cumbersome measurement procedures and the need for large sample volumes. We present a colorimetric method to measure the viscosity of blood plasma using a paper-based viscometer developed in this study specifically for clinical diagnosis. The proposed analytical device consists of multilayered papers with fluid-loading, -mixing, and -measuring regions, and it can be fabricated readily in a simple manner using three-layered paper channels and tape. Moreover, the colorimetric analysis enables viscosity estimations by analyzing a single optical image. To validate the device performance, we measured the viscosities of fluids such as glycerin aqueous solutions, bovine-serum-albumin solution, dimethyl sulfoxide, and blood plasma. We found that the measured viscosities were in good agreement with the reference values. Finally, we developed a simple smartphone application for the viscosity measurements that helped enhance the convenience and utility of the paper-based viscometer while maintaining the measurement accuracy.
URI
https://pubs.acs.org/doi/10.1021/acs.analchem.9b00624https://repository.hanyang.ac.kr/handle/20.500.11754/111685
ISSN
0003-2700; 1520-6882
DOI
10.1021/acs.analchem.9b00624
Appears in Collections:
RESEARCH INSTITUTE[S](부설연구소) > ETC
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE