Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 박찬혁 | - |
dc.date.accessioned | 2019-10-21T06:19:38Z | - |
dc.date.available | 2019-10-21T06:19:38Z | - |
dc.date.issued | 2019-01 | - |
dc.identifier.citation | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v. 34, NO 1, Page. 84-91 | en_US |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.issn | 1440-1746 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/full/10.1111/jgh.14471 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/111284 | - |
dc.description.abstract | Background and Aim A high yield of biopsy is mandatory to perform molecular genetic research with endoscopically obtained gastric cancer tissues. We evaluated whether probe-based confocal laser endomicroscopy (pCLE) can increase the yield of endoscopic biopsy for gastric cancer compared with white light endoscopy (WLE). Methods All lesions in the pCLE and WLE groups were initially evaluated through WLE. In the pCLE group, lesions were further examined through pCLE. In the pilot study, five and three biopsy specimens were obtained for histopathological examination and tumor marker analysis, respectively. In the confirmatory study, six biopsy specimens for histopathological evaluation were obtained. Results A total of 30 gastric cancers and 61 undifferentiated-type gastric cancers were analyzed in the pilot and confirmatory studies, respectively. The proportion of cancer cells in biopsy samples of poorly differentiated adenocarcinoma or signet ring cell carcinoma was higher in the pCLE group than in the WLE group in both the pilot and confirmatory studies (pilot: median proportion, 65% vs 30%, P = 0.010; confirmatory: mean +/- standard deviation, 49.5 +/- 29.3 vs 29.3 +/- 13.7, P = 0.002). The expression ratio of tumor markers including carcinoembryonic antigen, GW112, HOX transcript antisense RNA, and H19 tended to be higher in the pCLE group than in the WLE group. Conclusion Probe-based confocal laser endomicroscopy-targeted biopsy provided superior results in terms of the proportion of cancer cells in biopsy samples compared with WLE-targeted biopsy in gastric cancer with undifferentiated histology. | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY | en_US |
dc.subject | biopsy | en_US |
dc.subject | confocal laser endomicroscopy | en_US |
dc.subject | gastric cancer | en_US |
dc.subject | tumor marker | en_US |
dc.title | Role of probe-based confocal laser endomicroscopy-targeted biopsy in the molecular and histopathological study of gastric cancer | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 34 | - |
dc.identifier.doi | 10.1111/jgh.14471 | - |
dc.relation.page | 84-91 | - |
dc.relation.journal | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.contributor.googleauthor | Park, Chan Hyuk | - |
dc.contributor.googleauthor | Kim, Hyunki | - |
dc.contributor.googleauthor | Jo, Jeong Hyeon | - |
dc.contributor.googleauthor | Hahn, Kyu Yeon | - |
dc.contributor.googleauthor | Yoon, Jung-Ho | - |
dc.contributor.googleauthor | Kim, Soon Young | - |
dc.contributor.googleauthor | Lee, Yong Chan | - |
dc.contributor.googleauthor | Noh, Sung Hoon | - |
dc.contributor.googleauthor | Chung, Hyun Cheol | - |
dc.contributor.googleauthor | Lee, Sang Kil | - |
dc.relation.code | 2019000817 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | chan100 | - |
dc.identifier.researcherID | I-1794-2016 | - |
dc.identifier.orcid | http://orcid.org/0000-0003-3824-3481 | - |
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