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dc.contributor.author이영열-
dc.date.accessioned2019-10-21T00:51:57Z-
dc.date.available2019-10-21T00:51:57Z-
dc.date.issued2019-02-
dc.identifier.citationCANCERS, v. 11, NO 2, 200en_US
dc.identifier.issn2072-6694-
dc.identifier.urihttps://www.mdpi.com/2072-6694/11/2/200-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/111234-
dc.description.abstractThe separation of circulating tumor cells (CTCs) from the peripheral blood is an important issue that has been highlighted because of their high clinical potential. However, techniques that depend solely on tumor-specific surface molecules or just the larger size of CTCs are limited by tumor heterogeneity. Here, we present a slanted weir microfluidic device that utilizes the size and deformability of CTCs to separate them from the unprocessed whole blood. By testing its ability using a highly invasive breast cancer cell line, our device achieved a 97% separation efficiency, while showing an 8-log depletion of erythrocytes and 5.6-log depletion of leukocytes. We also developed an image analysis tool that was able to characterize the various morphologies and differing deformability of the separating cells. From the results, we believe our system possesses a high potential for liquid biopsy, aiding future cancer research.en_US
dc.description.sponsorshipThis research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT, and Future Planning (NRF-2017R1A2B4003189), and the Ministry of Education of Korea (NRF-2012R1A6A1029029).en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectcirculating tumor cellen_US
dc.subjectcell separationen_US
dc.subjectmicrofluidicsen_US
dc.titleContinuous Separation of Circulating Tumor Cells from Whole Blood Using a Slanted Weir Microfluidic Deviceen_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume11-
dc.identifier.doi10.3390/cancers11020200-
dc.relation.page1-13-
dc.relation.journalCANCERS-
dc.contributor.googleauthorYoon, Yousang-
dc.contributor.googleauthorLee, Jusin-
dc.contributor.googleauthorRa, Moonsoo-
dc.contributor.googleauthorGwon, Hyeokshin-
dc.contributor.googleauthorLee, Seungwon-
dc.contributor.googleauthorKim, Min Young-
dc.contributor.googleauthorYoo, Ki-Chun-
dc.contributor.googleauthorSul, Onejae-
dc.contributor.googleauthorKim, Chul Geun-
dc.contributor.googleauthorLee, Young Yiul-
dc.relation.code2019045118-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidleeyy-


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