Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박용순 | - |
dc.date.accessioned | 2019-10-07T08:15:13Z | - |
dc.date.available | 2019-10-07T08:15:13Z | - |
dc.date.issued | 2019-01 | - |
dc.identifier.citation | RENAL FAILURE, v. 41, NO 1, Page. 211-219 | en_US |
dc.identifier.issn | 0886-022X | - |
dc.identifier.issn | 1525-6049 | - |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/0886022X.2019.1591996 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/110903 | - |
dc.description.abstract | Aim: Stearoyl-CoA desaturase (SCD)-1 and elongase-6 (Elovl-6) are associated with fatty acid (FA) synthesis. We evaluated the effect of omega-3 FA on erythrocyte membrane FA contents through SCD-1 and Elovl-6 expression in the liver and kidney of a cyclosporine (CsA)-induced rat model. Methods: Male Sprague Dawley rats were divided into control, CsA, and CsA treated with omega-3 FA groups. We measured SCD-1 and Elovl-6 expression levels via western blot and immunohistochemistry analysis. Results: Erythrocyte membrane oleic acid content was lower in the CsA with omega-3 FA group compared to the CsA group. Compared to the control group, CsA-induced rats showed elevated SCD-1 expression in the kidney and liver, which omega-3 FA treatment reversed. Elovl-6 expression was increased in the liver, but decreased in the kidney in CsA group compared to control, which omega-3 FA treatment also reversed. Conclusions: Omega-3 FA supplementation decreased erythrocyte membrane oleic acid content by modulating SCD-1 and Elovl-6 expression in the kidney and liver of CsA-induced rats. | en_US |
dc.description.sponsorship | This study was supported by the Dong-A University Research Fund. | en_US |
dc.language.iso | en | en_US |
dc.publisher | TAYLOR & FRANCIS LTD | en_US |
dc.subject | Cyclosporine | en_US |
dc.subject | fatty acid | en_US |
dc.subject | kidney | en_US |
dc.subject | liver | en_US |
dc.subject | omega-3 | en_US |
dc.subject | oleic acid | en_US |
dc.title | Omega-3 fatty acid decreases oleic acid by decreasing SCD-1 expression in the liver and kidney of a cyclosporine-induced nephropathy rat model | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 41 | - |
dc.identifier.doi | 10.1080/0886022X.2019.1591996 | - |
dc.relation.page | 211-219 | - |
dc.relation.journal | RENAL FAILURE | - |
dc.contributor.googleauthor | Lee, Su Mi | - |
dc.contributor.googleauthor | Lee, Mi Hwa | - |
dc.contributor.googleauthor | Son, Young Ki | - |
dc.contributor.googleauthor | Kim, Seong Eun | - |
dc.contributor.googleauthor | Park, Yongsoon | - |
dc.contributor.googleauthor | Rha, Seo Hee | - |
dc.contributor.googleauthor | An, Won Suk | - |
dc.relation.code | 2019044403 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF HUMAN ECOLOGY[S] | - |
dc.sector.department | DEPARTMENT OF FOOD & NUTRITION | - |
dc.identifier.pid | yongsoon | - |
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