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Narrow-bore high performance liquid chromatographic method for the determination of cetirizine in human plasma using column switching

Title
Narrow-bore high performance liquid chromatographic method for the determination of cetirizine in human plasma using column switching
Author
김진기
Keywords
cetirizine; column switching; high performance liquid chromatography (HPLC); pharmacokinetics
Issue Date
2005-03
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, v. 37, No, 3, Page. 603-609
Abstract
An improved column switching high performance liquid chromatographic (HPLC) method was developed for determination of cetirizine in human plasma. Plasma samples were prepared by liquid-liquid extraction using methylene chloride. The samples extracted were initially injected into a clean-up Capcell Pak MF C-8 column and the peaks of cetirizine and internal standard were separated to an analytical C-8 micro-column via column switching device. This analysis showed highly sensitive and selective results. Also, it was successfully applied to evaluate the pharmacokinetics of cetirizine in human volunteers after single oral administration. (c) 2004 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S073170850400603Xhttps://repository.hanyang.ac.kr/handle/20.500.11754/110289
ISSN
0731-7085
DOI
10.1016/j.jpba.2004.11.022
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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