Continuous Fabrication of Biocatalyst Immobilized Microparticles Using Photopolymerization and Immiscible Liquids in Microfluidic Systems
- Title
- Continuous Fabrication of Biocatalyst Immobilized Microparticles Using Photopolymerization and Immiscible Liquids in Microfluidic Systems
- Author
- 이은규
- Issue Date
- 2005-03
- Publisher
- AMER CHEMICAL SOC
- Citation
- LANGMUIR, v. 21, No. 9, Page. 3738-3741
- Abstract
- We report a novel technique for manufacturing polymeric microparticles containing biocatalysts by the behavior of immiscible liquids in microfluidic systems and in situ photopolymerization. The approach utilizes a UV-polymerizable hydrogel/enzyme solution and an immiscible oil solution. The oil and hydrogel solutions form emulsions in pressure-driven flow in microchannels at high values of the dimensionless capillary number (Ca). The resultant hydrogel droplets are then polymerized in situ via exposure to 365 nm UV light. This technique allows for the generation of monodisperse particles whose size can be controlled by the regulation of flow rates. In addition, both manufacturing microparticles and immobilizing biocatalysts can be performed simultaneously and continuously.
- URI
- https://pubs.acs.org/doi/abs/10.1021/la050105lhttps://repository.hanyang.ac.kr/handle/20.500.11754/110266
- ISSN
- 0743-7463
- DOI
- 10.1021/la050105l
- Appears in Collections:
- COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > BIONANO ENGINEERING(생명나노공학과) > Articles
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