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dc.contributor.authorKUTZNER, ARNE HOLGER-
dc.date.accessioned2019-08-29T07:34:59Z-
dc.date.available2019-08-29T07:34:59Z-
dc.date.issued2019-01-
dc.identifier.citationCANCER GENETICS, v. 230 , Page. 1-12en_US
dc.identifier.issn2210-7762-
dc.identifier.issn2210-7770-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S2210776218303661?via%3Dihub-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/110053-
dc.description.abstractAdrenocortical carcinoma (ACC) is a rare and aggressive tumor whose molecular signaling pathways are not fully understood. Using an in-silico clinical data analysis approach we retrieved human gene mutation data from the highly reputed Cancer Genome Atlas (TCGA). ACC-specific gene mutations were correlated with proliferation marker FAM72 expression and Mutsig along with the algorithmic implementation of the 20/20 rule were used to validate their oncogenic potential. The newly identified oncogenic driver gene set (ZFPM1, LRIG1, CRIPAK, ZNF517, GARS and DGKZ), specifically and most repeatedly mutated in ACC, is involved in tumor suppression and cellular proliferation and thus could be useful for the prognosis and development of therapeutic approaches for the treatment of ACC.en_US
dc.description.sponsorshipThis study was supported by Hanyang University by providing a scholarship to C.S.R. and by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2015R1D1A1A01057243 and 201681D1A1B03932599).en_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.subjectAdrenal glanden_US
dc.subjectCRIPAKen_US
dc.subjectDGKZen_US
dc.subjectLRIG1en_US
dc.subjectOncogeneen_US
dc.subjectZFPM1en_US
dc.subjectZinc fingeren_US
dc.titleEstablishing a human adrenocortical carcinoma (ACC)-specific gene mutation signatureen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.cancergen.2018.10.005-
dc.relation.page1-12-
dc.relation.journalCANCER GENETICS-
dc.contributor.googleauthorRahane, Chinmay Satish-
dc.contributor.googleauthorKutzner, Arne-
dc.contributor.googleauthorHeese, Klaus-
dc.relation.code2019000082-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDEPARTMENT OF INFORMATION SYSTEMS-
dc.identifier.pidkutzner-
dc.identifier.orcidhttp://orcid.org/0000-0001-5061-6936-
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COLLEGE OF ENGINEERING[S](공과대학) > INFORMATION SYSTEMS(정보시스템학과) > Articles
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