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dc.contributor.authorKUTZNER, ARNE HOLGER-
dc.date.accessioned2019-08-29T07:26:54Z-
dc.date.available2019-08-29T07:26:54Z-
dc.date.issued2019-01-
dc.identifier.citationJOURNAL OF NEURO-ONCOLOGY, v. 141 , NO 1 , Page. 57-70en_US
dc.identifier.issn0167-594X-
dc.identifier.issn1573-7373-
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs11060-018-03029-3-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/110052-
dc.description.abstractIntroduction Glioblastoma multiform (GBM) is a neural stem cell (NSC)-derived malignant brain tumor with complex genetic alterations challenging clinical treatments. FAM72 is a NSC-specific protein comprised of four paralogous genes (FAM72 A-D) in the human genome, but its functional tumorigenic significance is unclear. Methods We conducted an in-depth expression and somatic mutation data analysis of FAM72 (A-D) in GBM using the comprehensive human clinical cancer study database cBioPortal [including The Cancer Genome Atlas (TCGA)]. Results We established a FAM72 transcription profile across TCGA correlated with the expression of the proliferative marker MKI67 and a tissue-specific gene-mutation signature represented by pivotal genes involved in driving the cell cycle. FAM72 paralogs are overexpressed in cancer cells, specifically correlating with the mitotic cell cycle genes ASPM, KIF14, KIF23, CENPE, CENPE, CEP55, SGO1, and BUB1, thereby contributing to centrosome and mitotic spindle formation. FAM72 expression correlation identifies a novel GBM-specific gene set (SCN9A, MXRA5, ADAM29, KDR, LRP1B, and PIK3C2G) in the de novo pathway of primary GBM predestined as viable targets for therapeutics. Conclusion Our newly identified primary GBM-specific gene-mutation signature, along with FAM72, could thus provide a new basis for prognostic biomarkers for diagnostics of GBM and could serve as potential therapeutic targets.en_US
dc.description.sponsorshipThis study was supported by Hanyang University by providing a scholarship to C.S.R. and by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2015R1D1A1A01057243 and 2016R1D1A1B03932599).en_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.subjectCanceren_US
dc.subjectGliaen_US
dc.subjectGlioblastomaen_US
dc.subjectNeuronen_US
dc.subjectSRGAP2en_US
dc.subjectStem cellsen_US
dc.subjectTCGAen_US
dc.titleA cancer tissue-specific FAM72 expression profile defines a novel glioblastoma multiform (GBM) gene-mutation signatureen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s11060-018-03029-3-
dc.relation.page57-70-
dc.relation.journalJOURNAL OF NEURO-ONCOLOGY-
dc.contributor.googleauthorRahane, Chinmay Satish-
dc.contributor.googleauthorKutzner, Arne-
dc.contributor.googleauthorHeese, Klaus-
dc.relation.code2019001963-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDEPARTMENT OF INFORMATION SYSTEMS-
dc.identifier.pidkutzner-
dc.identifier.orcidhttp://orcid.org/0000-0001-5061-6936-
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COLLEGE OF ENGINEERING[S](공과대학) > INFORMATION SYSTEMS(정보시스템학과) > Articles
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