Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김희태 | - |
dc.date.accessioned | 2019-08-27T05:31:35Z | - |
dc.date.available | 2019-08-27T05:31:35Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.citation | PARKINSONISM & RELATED DISORDERS, v. 60, Page. 87-91 | en_US |
dc.identifier.issn | 1353-8020 | - |
dc.identifier.issn | 1873-5126 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1353802018304061?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/109984 | - |
dc.description.abstract | Introduction: Even though gait symptoms are prominent in patients diagnosed with multiple system atrophy with predominant parkinsonism (MSA-P) compared with Parkinson's disease (PD), the gait patterns of MSA-P were not clearly elucidated. We investigated postural instability and gait disturbances in MSA-P compared with PD. Methods: We enrolled 34 drug-naive patients with PD and 26 with MSA-P, and 18 normal controls in this study. Parkinsonism was evaluated by the Unified Parkinson's disease rating scale (UPDRS) part 3 and cognition was assessed with mini-mental status exam (MMSE). All the enrolled subjects underwent Pedoscan and GAITRite to objectively measure postural stability and gait. We compared the results of posturography and gait analysis among 3 groups, and performed correlation analysis of gait parameters with MMSE, UPDRS part 3 and posturography results. Results: No difference was detected in demographic and clinical variables, except tremor sub-score of UPDRS part 3, urinary symptoms and orthostatic hypotension. MSA-P patients showed larger total anterior-posterior and lateral movement of centre of pressure (COP), and widened base of support than PD patients. In correlation analysis, MMSE score, axial sub-score of UPDRS part 3 and lateral movement of COP were correlated with gait parameters in PD patients, while only axial sub-score was associated in MSA-P patients after controlling for age, sex, height, body weight, education year, and disease duration. Conclusion: Even at an early stage, MSA-P patients demonstrated more postural instability and gait disturbance compared with PD patients, and the related factors with gait disturbance in PD and MSA-P might be different. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCI LTD | en_US |
dc.subject | Parkinson's disease | en_US |
dc.subject | Multiple system atrophy | en_US |
dc.subject | Gait | en_US |
dc.subject | Balance | en_US |
dc.subject | Parkinsonism | en_US |
dc.title | Comparison of gait parameters between drug-naive patients diagnosed with multiple system atrophy with predominant parkinsonism and Parkinson's disease | en_US |
dc.type | Article | en_US |
dc.relation.volume | 60 | - |
dc.identifier.doi | 10.1016/j.parkreldis.2018.09.018 | - |
dc.relation.page | 87-91 | - |
dc.relation.journal | PARKINSONISM & RELATED DISORDERS | - |
dc.contributor.googleauthor | Na, Boo Suk | - |
dc.contributor.googleauthor | Ha, Jongmok | - |
dc.contributor.googleauthor | Park, Ji-Hyung | - |
dc.contributor.googleauthor | Ahn, Jong Hyeon | - |
dc.contributor.googleauthor | Kim, Minkyeong | - |
dc.contributor.googleauthor | Kim, Ji Sun | - |
dc.contributor.googleauthor | Kim, Hee-Tae | - |
dc.contributor.googleauthor | Cho, Jin Whan | - |
dc.contributor.googleauthor | Youn, Jinyoung | - |
dc.relation.code | 2019040062 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kimht | - |
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