Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이민형 | - |
dc.date.accessioned | 2019-08-27T01:59:49Z | - |
dc.date.available | 2019-08-27T01:59:49Z | - |
dc.date.issued | 2019-04 | - |
dc.identifier.citation | NATURE NEUROSCIENCE, v. 22, NO 4, Page. 524-528 | en_US |
dc.identifier.issn | 1097-6256 | - |
dc.identifier.issn | 1546-1726 | - |
dc.identifier.uri | https://www.nature.com/articles/s41593-019-0352-0 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/109955 | - |
dc.description.abstract | In vivo gene editing in post-mitotic neurons of the adult brain may be a useful strategy for treating neurological diseases. Here, we develop CRISPR-Cas9 nanocomplexes and show they were effective in the adult mouse brain, with minimal off-target effects. Using this system to target Bacel suppressed amyloid beta (A beta)-associated pathologies and cognitive deficits in two mouse models of Alzheimer's disease. These results broaden the potential application of CRISPR-Cas9 systems to neurodegenerative diseases. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea funded by the Ministry of Education, Science, and Technology (grant nos. NRF-2017M3A9C6029306 and 2016R1A2B2014195), Korea Health Technology R&D Project, Ministry of Health & Welfare (grant no. HI16C1176). | en_US |
dc.language.iso | en | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | MICE | en_US |
dc.subject | EXPRESSION | en_US |
dc.subject | PROTEIN | en_US |
dc.subject | MUSCLE | en_US |
dc.title | In vivo neuronal gene editing via CRISPR-Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer's disease | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 22 | - |
dc.identifier.doi | 10.1038/s41593-019-0352-0 | - |
dc.relation.page | 524-524 | - |
dc.relation.journal | NATURE NEUROSCIENCE | - |
dc.contributor.googleauthor | Park, Hanseul | - |
dc.contributor.googleauthor | Oh, Jungju | - |
dc.contributor.googleauthor | Shim, Gayong | - |
dc.contributor.googleauthor | Cho, Byounggook | - |
dc.contributor.googleauthor | Chang, Yujung | - |
dc.contributor.googleauthor | Kim, Siyoung | - |
dc.contributor.googleauthor | Baek, Soonbong | - |
dc.contributor.googleauthor | Kim, Hongwon | - |
dc.contributor.googleauthor | Shin, Jeain | - |
dc.contributor.googleauthor | Lee, Minhyung | - |
dc.relation.code | 2019000599 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | minhyung | - |
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