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dc.contributor.author이영한-
dc.date.accessioned2019-08-27T01:57:15Z-
dc.date.available2019-08-27T01:57:15Z-
dc.date.issued2006-12-
dc.identifier.citationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v. 353, No. 3, Page. 611-616en_US
dc.identifier.issn0006-291X-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0006291X06027203-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/109954-
dc.description.abstractThe phospholipid hydrolase phospholipase Cγ1 (PLCγ1) plays a major role in regulation of cell proliferation, development, and cell motility. Overexpression of PLCγ1 is associated with tumor development, and it is overexpressed in some tumors. Matrix metalloproteinase-3 (MMP-3) is a protein involved in tumor invasion and metastasis. Here, we demonstrate that overexpression of PLCγ1 stimulates MMP-3 expression at the transcriptional level via the PKC-mediated Raf/MEK1/ERK signaling cascade. We propose that modulation of PLCγ1 activity might be of value in controlling the activity of MMPs, which are important regulators of invasion and metastasis in malignant tumors.en_US
dc.description.sponsorshipThis work was supported by the Korea Research Foundation Grant (KRF-2003-041-E00051) and by the research fund of Hanyang University (HY-2005-I). We thank Mr. Tae-Seop Shin for preparation of the MMP-3 promoter constructs.en_US
dc.language.isoen_USen_US
dc.publisherACADEMIC PRESS INCen_US
dc.subjectPLC gamma 1en_US
dc.subjectMMP-3en_US
dc.subjectprotein kinase Cen_US
dc.subjectMAPKen_US
dc.titlePhospholipase Cγ1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascadeen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bbrc.2006.12.064-
dc.relation.journalBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.contributor.googleauthorShin, Soon Young-
dc.contributor.googleauthorChoi, Ha Young-
dc.contributor.googleauthorAhn, Bong-Hyun-
dc.contributor.googleauthorMin, Do Sik-
dc.contributor.googleauthorSon, Sang Wook-
dc.contributor.googleauthorLee, Young Han-
dc.relation.code2008201235-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF SCIENCE & TECHNOLOGY[E]-
dc.sector.departmentDIVISION OF MOLECULAR & LIFE SCIENCE-
dc.identifier.pidyounghan-
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COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > ETC
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