Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이영한 | - |
dc.date.accessioned | 2019-08-27T01:57:15Z | - |
dc.date.available | 2019-08-27T01:57:15Z | - |
dc.date.issued | 2006-12 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v. 353, No. 3, Page. 611-616 | en_US |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0006291X06027203 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/109954 | - |
dc.description.abstract | The phospholipid hydrolase phospholipase Cγ1 (PLCγ1) plays a major role in regulation of cell proliferation, development, and cell motility. Overexpression of PLCγ1 is associated with tumor development, and it is overexpressed in some tumors. Matrix metalloproteinase-3 (MMP-3) is a protein involved in tumor invasion and metastasis. Here, we demonstrate that overexpression of PLCγ1 stimulates MMP-3 expression at the transcriptional level via the PKC-mediated Raf/MEK1/ERK signaling cascade. We propose that modulation of PLCγ1 activity might be of value in controlling the activity of MMPs, which are important regulators of invasion and metastasis in malignant tumors. | en_US |
dc.description.sponsorship | This work was supported by the Korea Research Foundation Grant (KRF-2003-041-E00051) and by the research fund of Hanyang University (HY-2005-I). We thank Mr. Tae-Seop Shin for preparation of the MMP-3 promoter constructs. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ACADEMIC PRESS INC | en_US |
dc.subject | PLC gamma 1 | en_US |
dc.subject | MMP-3 | en_US |
dc.subject | protein kinase C | en_US |
dc.subject | MAPK | en_US |
dc.title | Phospholipase Cγ1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.bbrc.2006.12.064 | - |
dc.relation.journal | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.contributor.googleauthor | Shin, Soon Young | - |
dc.contributor.googleauthor | Choi, Ha Young | - |
dc.contributor.googleauthor | Ahn, Bong-Hyun | - |
dc.contributor.googleauthor | Min, Do Sik | - |
dc.contributor.googleauthor | Son, Sang Wook | - |
dc.contributor.googleauthor | Lee, Young Han | - |
dc.relation.code | 2008201235 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE & TECHNOLOGY[E] | - |
dc.sector.department | DIVISION OF MOLECULAR & LIFE SCIENCE | - |
dc.identifier.pid | younghan | - |
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