Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2019-08-16T04:42:06Z | - |
dc.date.available | 2019-08-16T04:42:06Z | - |
dc.date.issued | 2006-10 | - |
dc.identifier.citation | ARCHIVES OF PHARMACAL RESEARCH, v. 29, No. 10, Page. 879-883 | en_US |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007/BF02973909 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/108688 | - |
dc.description.abstract | To develop a C-13-urea-containing capsule for more economic and sensitive diagnosis of Helicobacter pylon infection, the C-13-urea-containing capsules were prepared with various additives such as polyethylene glycol, microcrystalline cellulose, sodium lauryl sulfate and citric acid. Their dissolution test and C-13-urea Breath Test in human volunteers were then performed. Polyethylene glycol increased the initial dissolution rates of urea and difference delta C-13 values from C-13-urea, while microcrystalline cellulose and sodium lauryl sulfate decreased them. Irrespective of addition of citric acid, the compositions with polyethylene glycol showed higher values from C-13-urea compared to a commercial 76 mg C-13-urea-containing capsule due to higher initial dissolution rate. The capsules with 38 Mg C-13-urea and 1.9 mg polyethylene glycol, which showed higher Helicobacter pylori-positive value of about 8 parts per thousand at 10 min, improved the sensitivity of C-13-urea in human volunteers. Thus, the C-13-urea-containing capsule with polyethylene glycol would be a more economical and sensitive preparation for diagnosis of Helicobacter pylori infection. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | PHARMACEUTICAL SOCIETY KOREA | en_US |
dc.subject | Helicobacter pylori | en_US |
dc.subject | urea | en_US |
dc.subject | polyethylene glycol | en_US |
dc.subject | dissolution | en_US |
dc.subject | 13C-urea breath test | en_US |
dc.title | Trials of novel C-13-urea-containing capsule for more economic and sensitive diagnosis of Helicobacter pylori infection in human subjects | en_US |
dc.type | Article | en_US |
dc.relation.volume | 29 | - |
dc.identifier.doi | 10.1007/BF02973909 | - |
dc.relation.page | 879-883 | - |
dc.relation.journal | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.contributor.googleauthor | Yong, Chul Soon | - |
dc.contributor.googleauthor | Kim, Yong-Il | - |
dc.contributor.googleauthor | Park, San-Man | - |
dc.contributor.googleauthor | Kwon, Rham | - |
dc.contributor.googleauthor | Han, Hong-Hee | - |
dc.contributor.googleauthor | Park, Jung Gil | - |
dc.contributor.googleauthor | Yang, Chan-Yoo | - |
dc.contributor.googleauthor | Kim, Jung-Ae | - |
dc.contributor.googleauthor | Yoo, Bong-Kyu | - |
dc.contributor.googleauthor | Choi, Han-Gon | - |
dc.contributor.googleauthor | Rhee, Jong-Dal | - |
dc.relation.code | 2011200969 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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