Trials of novel C-13-urea-containing capsule for more economic and sensitive diagnosis of Helicobacter pylori infection in human subjects
- Title
- Trials of novel C-13-urea-containing capsule for more economic and sensitive diagnosis of Helicobacter pylori infection in human subjects
- Author
- 최한곤
- Keywords
- Helicobacter pylori; urea; polyethylene glycol; dissolution; 13C-urea breath test
- Issue Date
- 2006-10
- Publisher
- PHARMACEUTICAL SOCIETY KOREA
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v. 29, No. 10, Page. 879-883
- Abstract
- To develop a C-13-urea-containing capsule for more economic and sensitive diagnosis of Helicobacter pylon infection, the C-13-urea-containing capsules were prepared with various additives such as polyethylene glycol, microcrystalline cellulose, sodium lauryl sulfate and citric acid. Their dissolution test and C-13-urea Breath Test in human volunteers were then performed. Polyethylene glycol increased the initial dissolution rates of urea and difference delta C-13 values from C-13-urea, while microcrystalline cellulose and sodium lauryl sulfate decreased them. Irrespective of addition of citric acid, the compositions with polyethylene glycol showed higher values from C-13-urea compared to a commercial 76 mg C-13-urea-containing capsule due to higher initial dissolution rate. The capsules with 38 Mg C-13-urea and 1.9 mg polyethylene glycol, which showed higher Helicobacter pylori-positive value of about 8 parts per thousand at 10 min, improved the sensitivity of C-13-urea in human volunteers. Thus, the C-13-urea-containing capsule with polyethylene glycol would be a more economical and sensitive preparation for diagnosis of Helicobacter pylori infection.
- URI
- https://link.springer.com/article/10.1007/BF02973909https://repository.hanyang.ac.kr/handle/20.500.11754/108688
- ISSN
- 0253-6269
- DOI
- 10.1007/BF02973909
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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