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Trials of novel C-13-urea-containing capsule for more economic and sensitive diagnosis of Helicobacter pylori infection in human subjects

Title
Trials of novel C-13-urea-containing capsule for more economic and sensitive diagnosis of Helicobacter pylori infection in human subjects
Author
최한곤
Keywords
Helicobacter pylori; urea; polyethylene glycol; dissolution; 13C-urea breath test
Issue Date
2006-10
Publisher
PHARMACEUTICAL SOCIETY KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v. 29, No. 10, Page. 879-883
Abstract
To develop a C-13-urea-containing capsule for more economic and sensitive diagnosis of Helicobacter pylon infection, the C-13-urea-containing capsules were prepared with various additives such as polyethylene glycol, microcrystalline cellulose, sodium lauryl sulfate and citric acid. Their dissolution test and C-13-urea Breath Test in human volunteers were then performed. Polyethylene glycol increased the initial dissolution rates of urea and difference delta C-13 values from C-13-urea, while microcrystalline cellulose and sodium lauryl sulfate decreased them. Irrespective of addition of citric acid, the compositions with polyethylene glycol showed higher values from C-13-urea compared to a commercial 76 mg C-13-urea-containing capsule due to higher initial dissolution rate. The capsules with 38 Mg C-13-urea and 1.9 mg polyethylene glycol, which showed higher Helicobacter pylori-positive value of about 8 parts per thousand at 10 min, improved the sensitivity of C-13-urea in human volunteers. Thus, the C-13-urea-containing capsule with polyethylene glycol would be a more economical and sensitive preparation for diagnosis of Helicobacter pylori infection.
URI
https://link.springer.com/article/10.1007/BF02973909https://repository.hanyang.ac.kr/handle/20.500.11754/108688
ISSN
0253-6269
DOI
10.1007/BF02973909
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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