Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤지희 | - |
dc.date.accessioned | 2019-08-14T02:17:44Z | - |
dc.date.available | 2019-08-14T02:17:44Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v. 9, no. 5227 | en_US |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://www.nature.com/articles/s41598-019-41534-1 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/108580 | - |
dc.description.abstract | Systemic lupus erythematosus (SLE) is mediated by a chronic and dysregulated inflammatory response. Interleukin (IL)-17, a proinflammatory cytokine, and T helper (Th)17 cells are associated with chronic autoimmune diseases. We hypothesized that inhibition of IL-17 would decrease the numbers of T cell subsets that function as B-cell helpers, as well as B-cell differentiation into plasma cells and autoantibody expression. The IL-17 level was increased markedly in Roquin(san/san) mice. Loss of IL-17 in Roquin(san/san) mice improved nephritis by downregulating immunoglobulin (Ig)G, IgG1, and IgG2a production. Formation of germinal centers (GCs), and follicular B- and T-cell differentiation was reduced, whereas the number of regulatory T (Treg) cells and immature B cells was increased, by IL-17 deficiency in Roquin(san/san) mice. These results suggest that IL-17 inhibition can ameliorate SLE by inhibiting B- cell differentiation into GCs. Therefore, IL-17-producing Th17 cells show promise as a target for development of novel therapeutics for SLE. | en_US |
dc.description.sponsorship | We thank the Institutional Animal Care and Use Committee, School of Medicine, Catholic University of Korea, for help with animal care and study. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2017R1A2B3007688), Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2015R1C1A2A01051677). | en_US |
dc.language.iso | en | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | HELPER T-CELLS | en_US |
dc.subject | GAMMA | en_US |
dc.subject | AUTOIMMUNITY | en_US |
dc.subject | MORTALITY | en_US |
dc.subject | FAMILY | en_US |
dc.subject | COHORT | en_US |
dc.title | Inhibition of IL-17 ameliorates systemic lupus erythematosus in Roquin(san/san) mice through regulating the balance of TFH cells, GC B cells, Treg and Breg | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 9 | - |
dc.identifier.doi | 10.1038/s41598-019-41534-1 | - |
dc.relation.page | 1-8 | - |
dc.relation.journal | SCIENTIFIC REPORTS | - |
dc.contributor.googleauthor | Lee, Seon-yeong | - |
dc.contributor.googleauthor | Lee, Seung Hoon | - |
dc.contributor.googleauthor | Seo, Hyeon-Beom | - |
dc.contributor.googleauthor | Ryu, Jun-Geol | - |
dc.contributor.googleauthor | Jung, KyungAh | - |
dc.contributor.googleauthor | Choi, Jeong Won | - |
dc.contributor.googleauthor | Jhun, JooYeon | - |
dc.contributor.googleauthor | Park, Jin-Sil | - |
dc.contributor.googleauthor | Kwon, Ji Ye | - |
dc.contributor.googleauthor | Youn, Jeehee | - |
dc.relation.code | 2019002548 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jhyoun | - |
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