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HuR stabilizes a polyadenylated form of replication-dependent histone mRNAs under stress conditions

Title
HuR stabilizes a polyadenylated form of replication-dependent histone mRNAs under stress conditions
Author
남진우
Keywords
mRNA stability; 39UTR; Polyadenylation signal; UVC
Issue Date
2019-02
Publisher
FEDERATION AMER SOC EXP BIOL
Citation
FASEB JOURNAL, v. 33, NO 2, Page. 2680-2693
Abstract
All metazoan mRNAs have a poly(A) tail at the 39 endwith the exception of replication-dependent histone (RDH) mRNAs, which end in a highly conserved stem-loop (SL) structure. However, a subset of RDH mRNAs are reported to be polyadenylated under physiologic conditions. The molecular details of the biogenesis of polyadenylated RDH [poly(A)+ RDH] mRNAs remain unknown. In this study, our genome-wide analyses reveal that puromycin treatment or UVC irradiation stabilizes poly(A)+ RDH mRNAs, relative to canonical RDH mRNAs,which end in an SL structure.We demonstrate that the stabilization of poly(A)+RDHmRNAs occurs in a translationindependent manner and is regulated via human antigen R (HuR) binding to the extended 39 UTR under stress conditions. Our data suggest that HuR regulates the expression of poly(A)+ RDH mRNAs.—Ryu, I., Park, Y.,Seo, J.-W., Park, O. H., Ha, H., Nam, J.-W., Kim, Y. K. HuR stabilizes a polyadenylated form of replication-dependent histone mRNAs under stress conditions. FASEB J. 33, 2680–2693 (2019). www.fasebj.org
URI
https://www.fasebj.org/doi/10.1096/fj.201800431Rhttps://repository.hanyang.ac.kr/handle/20.500.11754/108480
ISSN
0892-6638; 1530-6860
DOI
10.1096/fj.201800431R
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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