HuR stabilizes a polyadenylated form of replication-dependent histone mRNAs under stress conditions
- Title
- HuR stabilizes a polyadenylated form of replication-dependent histone mRNAs under stress conditions
- Author
- 남진우
- Keywords
- mRNA stability; 39UTR; Polyadenylation signal; UVC
- Issue Date
- 2019-02
- Publisher
- FEDERATION AMER SOC EXP BIOL
- Citation
- FASEB JOURNAL, v. 33, NO 2, Page. 2680-2693
- Abstract
- All metazoan mRNAs have a poly(A) tail at the 39 endwith the exception of replication-dependent histone (RDH) mRNAs, which end in a highly conserved stem-loop (SL) structure. However, a subset of RDH mRNAs are reported to be polyadenylated under physiologic conditions. The molecular details of the biogenesis of polyadenylated RDH [poly(A)+ RDH] mRNAs remain unknown. In this study, our genome-wide analyses reveal that puromycin treatment or UVC irradiation stabilizes poly(A)+ RDH mRNAs, relative to canonical RDH mRNAs,which end in an SL structure.We demonstrate that the stabilization of poly(A)+RDHmRNAs occurs in a translationindependent manner and is regulated via human antigen R (HuR) binding to the extended 39 UTR under stress conditions. Our data suggest that HuR regulates the expression of poly(A)+ RDH mRNAs.—Ryu, I., Park, Y.,Seo, J.-W., Park, O. H., Ha, H., Nam, J.-W., Kim, Y. K. HuR stabilizes a polyadenylated form of replication-dependent histone mRNAs under stress conditions. FASEB J. 33, 2680–2693 (2019). www.fasebj.org
- URI
- https://www.fasebj.org/doi/10.1096/fj.201800431Rhttps://repository.hanyang.ac.kr/handle/20.500.11754/108480
- ISSN
- 0892-6638; 1530-6860
- DOI
- 10.1096/fj.201800431R
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML