Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이용구 | - |
dc.date.accessioned | 2019-08-02T05:45:20Z | - |
dc.date.available | 2019-08-02T05:45:20Z | - |
dc.date.issued | 2019-02 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 277, Page. 240-246 | en_US |
dc.identifier.issn | 0167-5273 | - |
dc.identifier.issn | 1874-1754 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0167527318341767?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/108147 | - |
dc.description.abstract | Background: Inflammation has been reported to cause atrial fibrillation (AF). However, it remains unclear whether C-reactive protein (CRP) levels predict AF. We investigated whether there was an association between serum CRP levels and the development of AF. Methods: A total of 10,030 subjects aged between 40 and 69 years were enrolled and followed biennially over a 12-year period in the Ansan-Ansung cohort study. Serum CRP levels were measured at baseline and high sensitivity CRP (hsCRP) levels were measured at every revisit. AF was identified using 12-lead standard electrocardiography. Inverse probability of treatment weighting was applied to balance the confounders of AF development between groups. Results: Serum CRP levels were higher in subjects with AF at baseline and those with new-onset AF than in those without AF. Cox-regression analysis showed that high CRP levels (˃3 mg/L) and intermediate CRP levels (1-3 mg/L) at baseline were not associated with a higher risk of new-onset AF compared with low CRP levels (˂1 mg/L) after adjustments for covariates. The weighted incidences of AF also did not differ according to the CRP levels. In contrast, persistent elevation of CRP or hsCRP levels (˃= 1 mgiL at all visits) was associated with a higher risk of AF compared with nonpersistent elevation of CRP or hsCRP levels after adjustment for covariates in both unweighted and weighted cohorts. Conclusion: A high CRP level at a single measurement was not associated with the risk of AF, whereas persistently elevated CRP levels independently predicted the development of AF. (C) 2018 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by grants from the National Research Foundation of Korea (NRF) and funded by the Korean government (MSIP; Ministry of Science, ICT & Future Planning) (No. NRF-2017R1C1B5017115, NRF-2018R1C1B5047123). The authors thank all the participants and research staff of the Institute of Human Genomic Study at Ansan Hospital of Korea University. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER IRELAND LTD | en_US |
dc.subject | Atrial fibrillation | en_US |
dc.subject | C-reactive protein | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Ansan-Ansung study | en_US |
dc.title | Single and persistent elevation of C-reactive protein levels and the risk of atrial fibrillation in a general population: The Ansan-Ansung Cohort of the Korean Genome and Epidemiology Study | en_US |
dc.type | Article | en_US |
dc.relation.volume | 277 | - |
dc.identifier.doi | 10.1016/j.ijcard.2018.10.070 | - |
dc.relation.page | 240-246 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF CARDIOLOGY | - |
dc.contributor.googleauthor | Lee, Yonggu | - |
dc.contributor.googleauthor | Park, Hwan-Cheol | - |
dc.contributor.googleauthor | Shin, Jeong-Hun | - |
dc.contributor.googleauthor | Lim, Young-Hyo | - |
dc.contributor.googleauthor | Shin, Jinho | - |
dc.contributor.googleauthor | Park, Jin-Kyu | - |
dc.relation.code | 2019001098 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hmedi97 | - |
dc.identifier.researcherID | Q-3832-2018 | - |
dc.identifier.orcid | http://orcid.org/0000-0002-3757-3692 | - |
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