Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이영한 | - |
dc.date.accessioned | 2019-07-31T07:12:58Z | - |
dc.date.available | 2019-07-31T07:12:58Z | - |
dc.date.issued | 2006-05 | - |
dc.identifier.citation | CELLULAR SIGNALLING, v. 18, No. 5, Page. 601-607 | en_US |
dc.identifier.issn | 0898-6568 | - |
dc.identifier.issn | 1873-3913 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S089865680500135X | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/108064 | - |
dc.description.abstract | Hydrogen peroxide (H(2)O(2)) mediates induction of cytotoxicity in various cell types. GSK-3beta has been found to participate in a number of signaling pathways, including cell proliferation and cell death. In the present study, we show that GSK-3beta is rapidly dephosphorylated and activated in response to H(2)O(2) treatment. H(2)O(2) also dephosphorylates Akt/PKB in a dose- and time-dependent manner. Overexpression of Akt/PKB attenuates H(2)O(2)-induced dephosphorylation of GSK-3beta. Ectopic expression of Dvl-1, a component of Wnt signaling, stimulates Akt/PKB and inhibits dephosphorylation of GSK-3beta by H(2)O(2). Furthermore, H(2)O(2) causes the reduction of beta-catenin level and LiCl-mediated activation of Tcf/Lef-dependent transcription activity. These findings suggest that GSK-3beta is involved in H(2)O(2)-mediated inhibition of Tcf/Lef-dependent transcriptional activity. | en_US |
dc.description.sponsorship | This work was supported by a grant from the Brain Research Center of the 21st Century Frontier Research Program, funded by the Korean Ministry of Science and Technology (Grant No. M103KV010007-03K2201-00740). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE INC | en_US |
dc.subject | Hydrogen peroxide | en_US |
dc.subject | GSK-3β | en_US |
dc.subject | Akt/PKB | en_US |
dc.subject | Dvl-1 | en_US |
dc.subject | LiCl | en_US |
dc.subject | Wnt | en_US |
dc.subject | β-catenin | en_US |
dc.subject | Tcf/Lef | en_US |
dc.title | Involvement of glycogen synthase kinase-3β in hydrogen peroxide-induced suppression of Tcf/Lef-dependent transcriptional activity | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.cellsig.2005.06.001 | - |
dc.relation.journal | CELLULAR SIGNALLING | - |
dc.contributor.googleauthor | Shin, Soon Young | - |
dc.contributor.googleauthor | Chin, Byung Rho | - |
dc.contributor.googleauthor | Lee, Young Han | - |
dc.contributor.googleauthor | Kim, Jung-Hye | - |
dc.relation.code | 2009201756 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE & TECHNOLOGY[E] | - |
dc.sector.department | DIVISION OF MOLECULAR & LIFE SCIENCE | - |
dc.identifier.pid | younghan | - |
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