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Involvement of glycogen synthase kinase-3β in hydrogen peroxide-induced suppression of Tcf/Lef-dependent transcriptional activity

Title
Involvement of glycogen synthase kinase-3β in hydrogen peroxide-induced suppression of Tcf/Lef-dependent transcriptional activity
Author
이영한
Keywords
Hydrogen peroxide; GSK-3β; Akt/PKB; Dvl-1; LiCl; Wnt; β-catenin; Tcf/Lef
Issue Date
2006-05
Publisher
ELSEVIER SCIENCE INC
Citation
CELLULAR SIGNALLING, v. 18, No. 5, Page. 601-607
Abstract
Hydrogen peroxide (H(2)O(2)) mediates induction of cytotoxicity in various cell types. GSK-3beta has been found to participate in a number of signaling pathways, including cell proliferation and cell death. In the present study, we show that GSK-3beta is rapidly dephosphorylated and activated in response to H(2)O(2) treatment. H(2)O(2) also dephosphorylates Akt/PKB in a dose- and time-dependent manner. Overexpression of Akt/PKB attenuates H(2)O(2)-induced dephosphorylation of GSK-3beta. Ectopic expression of Dvl-1, a component of Wnt signaling, stimulates Akt/PKB and inhibits dephosphorylation of GSK-3beta by H(2)O(2). Furthermore, H(2)O(2) causes the reduction of beta-catenin level and LiCl-mediated activation of Tcf/Lef-dependent transcription activity. These findings suggest that GSK-3beta is involved in H(2)O(2)-mediated inhibition of Tcf/Lef-dependent transcriptional activity.
URI
https://www.sciencedirect.com/science/article/pii/S089865680500135Xhttps://repository.hanyang.ac.kr/handle/20.500.11754/108064
ISSN
0898-6568; 1873-3913
DOI
10.1016/j.cellsig.2005.06.001
Appears in Collections:
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > ETC
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