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dc.contributor.author하정미-
dc.date.accessioned2019-07-25T05:53:34Z-
dc.date.available2019-07-25T05:53:34Z-
dc.date.issued2006-05-
dc.identifier.citationJOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v. 128, No. 18, Page. 5996-5997en_US
dc.identifier.issn0002-7863-
dc.identifier.urihttps://pubs.acs.org/doi/abs/10.1021/ja060136i-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/107873-
dc.description.abstractA “global” strategy for the acquisition of selective high affinity inhibitors for the Src kinase subfamily of tyrosine kinases is described. Members of the Src family exhibit a strong amino acid sequence homology. However, recent studies have revealed differences in the relative spatial relationships of the three distinct protein-binding domains present in these enzymes. We have constructed an inhibitor, using an amalgamation of combinatorial methods and directed design, which simultaneously associates with the active site and an ancillary protein-binding region (SH2 domain). The inhibitor exhibits high inhibitory potency and selectivity for the Group A versus Group B subset of Src kinases.en_US
dc.language.isoen_USen_US
dc.publisherAMER CHEMICAL SOCen_US
dc.titleAcquisition of a Group A-selective Src Kinase Inhibitor via a Global Targeting Strategyen_US
dc.typeArticleen_US
dc.relation.volume128-
dc.identifier.doi10.1021/ja060136i-
dc.relation.page5996-5997-
dc.relation.journalJOURNAL OF THE AMERICAN CHEMICAL SOCIETY-
dc.contributor.googleauthorHah, Jung-Mi-
dc.contributor.googleauthorSharma, Vyas-
dc.contributor.googleauthorLi, Haishan-
dc.contributor.googleauthorLawrence, David S.-
dc.relation.code2009205895-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidjhah-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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