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Interaction of ε−L−β−lysine as a Tail Analogy of Tallysomycin-A to a Double Helical DNA Oligonucletide d(CGCTTCGAAGCG)2, was investigated by NMR

Title
Interaction of ε−L−β−lysine as a Tail Analogy of Tallysomycin-A to a Double Helical DNA Oligonucletide d(CGCTTCGAAGCG)2, was investigated by NMR
Author
원호식
Keywords
NMR; β-lysine; DNA; Interaction
Issue Date
2007-12
Publisher
한국자기공명학회
Citation
Journal of the Korean Magnetic Resonance Society, v. 11, No. 2, Page. 129-137
Abstract
During the screening of material which has the antimicrobial activity against aminoglycoside-resistant bacteria, A new material ε−(L−β−lysine) polypeptide from a culture medium of Streptomyces sp.(DWGS2) was isolated, and the structure and the physicochemical properties of the new material were elucidated. The new material was separated by column chromatography of the culture medium using Dowex 1×2, Silica gel, and Sephadex LH20 etc. The structure and molecular weight were determined with the data of NMR, MALDI mass, and ESI mass experiments. And the monomer obtained by hydrolysis of the new material with 6N-HCI was identified as a L−β−lysine(T2), which is a tail of bleomycin. As tail-region analogy, T2(β−lysine derivatives from streptomyces) interactions with a self-complementary oligonucleotides, d(CGCTTCGAAGCG)2, was investigated by NMR.
URI
http://www.koreascience.or.kr/article/JAKO200709905994459.pagehttps://repository.hanyang.ac.kr/handle/20.500.11754/107507
ISSN
1226-6531
Appears in Collections:
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > CHEMICAL AND MOLECULAR ENGINEERING(화학분자공학과) > Articles
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