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Proinvasive extracellular matrix remodeling for tumor progression

Title
Proinvasive extracellular matrix remodeling for tumor progression
Author
이수재
Keywords
Extracellular matrix; Metastatic cancer; Cancer stem cells; Hypoxia; Immune cells
Issue Date
2019-01
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v. 42, NO. 1, Page. 40-47
Abstract
Cancer is a systemic disease in which neoplastic cells interact with multiple types of non-neoplastic stromal cells as well as non-cellular components. The extracellular matrix (ECM) is a non-cellular component that is aberrantly regulated in many types of tumor microenvironments. Since the ECM generally maintains the tissue structure and provides mechanical forces in the tumor microenvironment, it has been simply assumed to act as a physical barrier for cancer metastasis and have a passive role in cancer progression. However, a substantial body of evidence has suggested that ECM remodeling influences many aspects of cancer cell behaviors and its importance has attracted attention in cancer biology. Abnormal ECM affects cancer progression through several ways such as inducing hypoxia, immune cells interaction by promoting mesenchymal shift and cell transformation. Accordingly, in this review we summarize and discusses the role of the ECM in modulating epithelial cells and surrounding stomatal cell components and considers its prospects in cancer biology.
URI
https://link.springer.com/article/10.1007%2Fs12272-018-1097-0https://repository.hanyang.ac.kr/handle/20.500.11754/107279
ISSN
1976-3786; 0253-6269
DOI
10.1007/s12272-018-1097-0
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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