68 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author유혜현-
dc.date.accessioned2019-06-24T07:30:11Z-
dc.date.available2019-06-24T07:30:11Z-
dc.date.issued2007-08-
dc.identifier.citationJOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, v. 70, No. 15-16, Page. 1310-1318en_US
dc.identifier.issn1528-7394-
dc.identifier.issn1087-2620-
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/15287390701434364-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/106839-
dc.description.abstractSphingolipid metabolites in HL-60 cells were analyzed to gain an understanding of their roles in early events underlying hydrogen peroxide (H2O2)-induced apoptosis. Incubation of cells with H2O2 increased the intracellular levels of ceramides and sphinganine, but decreased those of ceramide 1-phosphates (ceramide 1-P) and sphingosine. The levels of sphingomyelins and sphingo- myelinase (SMase) activities were not affected by H2O2 treatment. These results were similar to the profiles induced by daunorubicin, an activator of serine palmitoyl CoA transferase (SPT), suggesting that H2O2 stimulated the de novo synthetic pathway of ceramides. L-cycloserine and fumonisin B, (FBI), specific inhibitors of de novo ceramide biosynthesis, suppressed the elevation of ceramides and sphinganine induced by 112021 which consequently reduced apoptotic cell death. Collectively, these results demonstrated that H2O2 increased the intracellular concentrations of ceramides via activation of a de novo biosynthetic pathway, and the enhanced ceramides might initiate apoptosis in HL-60 cells.en_US
dc.description.sponsorshipThis work was supported in part by grants from Seoul Metropolitan City and in part by the intra-mural research program of the Korea Institute of Science and Technology.en_US
dc.language.isoen_USen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.titleActivation of de novo synthetic pathway of ceramides is responsible for the initiation of hydrogen peroxide induced apoptosis in HI-60 cellsen_US
dc.typeArticleen_US
dc.relation.volume70-
dc.identifier.doi10.1080/15287390701434364-
dc.relation.page1310-1318-
dc.relation.journalJOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES-
dc.contributor.googleauthorSon, Jung Hyun-
dc.contributor.googleauthorYoo, Hye Hyun-
dc.contributor.googleauthorKim, Dong-Hyun-
dc.relation.code2007214139-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidyoohh-
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE