Short communication: In vivo evaluation of microemulsion system for oral and parenteral delivery of rutaecarpine to rats
- Title
- Short communication: In vivo evaluation of microemulsion system for oral and parenteral delivery of rutaecarpine to rats
- Author
- 최한곤
- Keywords
- microemulsion; rutaecarpine; pharmacokinetics
- Issue Date
- 2007-05
- Publisher
- TAYLOR & FRANCIS INC
- Citation
- DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, v. 33, No. 5, Page. 531-534
- Abstract
- Rutaecarpine-loaded microemulsion composed of 10.8% polyethylene glycol 400, 7.2% Tween 80, 20% caster oil, and 62% water were previously reported to be physically and chemically stable for at least 6 months. For the development of a Rutaecarpine-loaded microemulsion, here we studied the pharmacokinetic profiles of rutaecarpine after oral and intravenous administration of rutaecarpine-loaded microemulsion compared to suspension. The AUC of rutaecarpine from microemulsion after oral and intravenous administration increased about three-fold compared with that from suspension. Furthermore, the rutaecarpine-loaded microemulsion gave significantly higher AUC and C-max than did suspension, suggesting that the oral bioavailability of rutaecarpine in this microemulsion system could be enhanced due to the enhanced solubility of rutaecarpine by microemulsion. Thus, our results indicated that the microemulsion system composed of castor oil, polyethylene glycol 400, Tween 80, and water could be a more effective oral and parenteral dosage form for rutaecarpine.
- URI
- https://www.tandfonline.com/doi/full/10.1080/03639040600865199https://repository.hanyang.ac.kr/handle/20.500.11754/106498
- ISSN
- 0363-9045
- DOI
- 10.1080/03639040600865199
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML