Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김종호 | - |
dc.date.accessioned | 2019-06-10T01:53:45Z | - |
dc.date.available | 2019-06-10T01:53:45Z | - |
dc.date.issued | 2007-03 | - |
dc.identifier.citation | JOURNAL OF COMBINATORIAL CHEMISTRY, v. 9, No. 2, Page. 237-244 | en_US |
dc.identifier.issn | 1520-4766 | - |
dc.identifier.uri | https://pubs.acs.org/doi/abs/10.1021/cc0600831 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/106330 | - |
dc.description.abstract | A new type of encoded bead, which uses surface-enhanced Raman scattering (SERS), is described for multiplex immunoassays. Silver nanoparticles were embedded in sulfonated polystyrene (PS) beads via a polyol method, and they were used as SERS-active substrates. Raman-label organic compounds such as 4-methylbenzenethiol (4-MT), 2-naphthalenethiol (2-NT), and benzenethiol (BT) were then adsorbed onto the silver nanoparticles in the sulfonated PS bead. Although only three kinds of encoding have been demonstrated here, various combinations of these Raman-label organic compounds have the potential to give a large number of tags. The Raman-label-incorporated particles were then coated with a silica shell using tetraethoxyorthosilicate (TEOS) for chemical stability and biocompatibility. The resulting beads showed unique and intense Raman signals for the labeled organic compounds. We demonstrated that SERS-encoded beads could be used for multiplex detection with a model using streptavidin and p53. In our system, the binding event of target molecules and the type of ligand can be simultaneously recognized by Raman spectroscopy using a single laser-line excitation (514.5 nm). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | AMER CHEMICAL SOC | en_US |
dc.subject | PERFORMANCE LIQUID-CHROMATOGRAPHY | en_US |
dc.subject | MONODISPERSE POLYMER BEADS | en_US |
dc.subject | BUNDLE IMAGE COMPRESSION | en_US |
dc.subject | SOLID-PHASE REACTIONS | en_US |
dc.subject | COMBINATORIAL CHEMISTRY | en_US |
dc.subject | SENSITIVE DETECTION | en_US |
dc.subject | ORGANIC-SYNTHESIS | en_US |
dc.subject | PACKING MATERIAL | en_US |
dc.subject | SCATTERING | en_US |
dc.subject | NANOPARTICLES | en_US |
dc.title | Surface-enhanced Raman spectroscopic-encoded beads for multiplex immunoassay | en_US |
dc.type | Article | en_US |
dc.relation.volume | 9 | - |
dc.identifier.doi | 10.1021/cc0600831 | - |
dc.relation.page | 237-244 | - |
dc.relation.journal | JOURNAL OF COMBINATORIAL CHEMISTRY | - |
dc.contributor.googleauthor | Jun, Bong-Hyun | - |
dc.contributor.googleauthor | Kim, Jong-Ho | - |
dc.contributor.googleauthor | Park, Hyunmi | - |
dc.contributor.googleauthor | Kim, Jun-Sung | - |
dc.contributor.googleauthor | Yu, Kyeong-Nam | - |
dc.contributor.googleauthor | Lee, Sang-Myung | - |
dc.contributor.googleauthor | Choi, Heejeong | - |
dc.contributor.googleauthor | Kwak, Seon-Yeong | - |
dc.contributor.googleauthor | Kim, Yong-Kweon | - |
dc.contributor.googleauthor | Jeong, Dae Hong | - |
dc.contributor.googleauthor | Cho, Myung-Haing | - |
dc.contributor.googleauthor | Lee, Yoon-Sik | - |
dc.relation.code | 2007204871 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF ENGINEERING SCIENCES[E] | - |
dc.sector.department | DEPARTMENT OF MATERIALS SCIENCE AND CHEMICAL ENGINEERING | - |
dc.identifier.pid | kjh75 | - |
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