Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2019-06-04T02:40:18Z | - |
dc.date.available | 2019-06-04T02:40:18Z | - |
dc.date.issued | 2007-02 | - |
dc.identifier.citation | APOPTOSIS, v. 12, No. 2, Page. 423-431 | en_US |
dc.identifier.issn | 1360-8185 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007/s10495-006-0620-9 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/106261 | - |
dc.description.abstract | Sulindac sulfone (also known as exisulind) and its chemical derivatives are promising anticancer agents capable of inducing apoptosis in a variety of malignant cell types with minimal toxicity to normal cells. Here, we tested the ability of alpha-tocopheryl succinate (TOS), another promising anticancer agent, to sensitize colon cancer cells to exisulind-induced apoptosis. We found that sub-apoptotic doses of TOS greatly enhanced exisulind-induced growth suppression and apoptosis in the HCT116, LoVo and SNU-C4 human colon cancer cell lines. Our results revealed that this was accounted for primarily by an augmented cleavage of poly(ADP-ribose) polymerase (PARP) and enhanced activation of caspase-8, -9 and -3. Pretreatment with z-VAD-FMK (a pan-caspase inhibitor), z-IETD-FMK (a caspase-8 inhibitor) or z-LEHD-FMK (a caspase-9 inhibitor) blocked TOS and exisulind cotreatment-induced PARP cleavage and apoptosis. Furthermore, TOS/exisulind cotreatment induced JNK phosphorylation, while pretreatment with SP600151 (a JNK inhibitor) partially blocked cotreatment-induced caspase-dependent PARP cleavage and apoptosis. Taken together, these findings indicate that TOS sensitizes human colon cancer cells to exisulind-induced apoptosis. Apoptotic synergy induced by exisulind plus TOS seems likely to be mediated through a mechanism involving activation of caspases and JNK. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | SPRINGER | en_US |
dc.subject | exisulind | en_US |
dc.subject | alpha-tocopheryl succinate | en_US |
dc.subject | apoptosis | en_US |
dc.subject | caspase | en_US |
dc.subject | JNK | en_US |
dc.subject | colon cancer | en_US |
dc.title | Alpha-tocopheryl succinate sensitizes human colon cancer cells to exisulind-induced apoptosis | en_US |
dc.type | Article | en_US |
dc.relation.volume | 12 | - |
dc.identifier.doi | 10.1007/s10495-006-0620-9 | - |
dc.relation.page | 423-431 | - |
dc.relation.journal | APOPTOSIS | - |
dc.contributor.googleauthor | Lim, Soo-Jeong | - |
dc.contributor.googleauthor | Lee, Young-Ju | - |
dc.contributor.googleauthor | Park, Dae-Hun | - |
dc.contributor.googleauthor | Lee, Eunmyong | - |
dc.contributor.googleauthor | Choi, Moon-Kyung | - |
dc.contributor.googleauthor | Park, Wanseo | - |
dc.contributor.googleauthor | Chun, Kyung-Hee | - |
dc.contributor.googleauthor | Choi, Han-Gon | - |
dc.contributor.googleauthor | Cho, Jung Sik | - |
dc.relation.code | 2007200817 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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