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dc.contributor.author최한곤-
dc.date.accessioned2019-06-04T02:40:18Z-
dc.date.available2019-06-04T02:40:18Z-
dc.date.issued2007-02-
dc.identifier.citationAPOPTOSIS, v. 12, No. 2, Page. 423-431en_US
dc.identifier.issn1360-8185-
dc.identifier.urihttps://link.springer.com/article/10.1007/s10495-006-0620-9-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/106261-
dc.description.abstractSulindac sulfone (also known as exisulind) and its chemical derivatives are promising anticancer agents capable of inducing apoptosis in a variety of malignant cell types with minimal toxicity to normal cells. Here, we tested the ability of alpha-tocopheryl succinate (TOS), another promising anticancer agent, to sensitize colon cancer cells to exisulind-induced apoptosis. We found that sub-apoptotic doses of TOS greatly enhanced exisulind-induced growth suppression and apoptosis in the HCT116, LoVo and SNU-C4 human colon cancer cell lines. Our results revealed that this was accounted for primarily by an augmented cleavage of poly(ADP-ribose) polymerase (PARP) and enhanced activation of caspase-8, -9 and -3. Pretreatment with z-VAD-FMK (a pan-caspase inhibitor), z-IETD-FMK (a caspase-8 inhibitor) or z-LEHD-FMK (a caspase-9 inhibitor) blocked TOS and exisulind cotreatment-induced PARP cleavage and apoptosis. Furthermore, TOS/exisulind cotreatment induced JNK phosphorylation, while pretreatment with SP600151 (a JNK inhibitor) partially blocked cotreatment-induced caspase-dependent PARP cleavage and apoptosis. Taken together, these findings indicate that TOS sensitizes human colon cancer cells to exisulind-induced apoptosis. Apoptotic synergy induced by exisulind plus TOS seems likely to be mediated through a mechanism involving activation of caspases and JNK.en_US
dc.language.isoen_USen_US
dc.publisherSPRINGERen_US
dc.subjectexisulinden_US
dc.subjectalpha-tocopheryl succinateen_US
dc.subjectapoptosisen_US
dc.subjectcaspaseen_US
dc.subjectJNKen_US
dc.subjectcolon canceren_US
dc.titleAlpha-tocopheryl succinate sensitizes human colon cancer cells to exisulind-induced apoptosisen_US
dc.typeArticleen_US
dc.relation.volume12-
dc.identifier.doi10.1007/s10495-006-0620-9-
dc.relation.page423-431-
dc.relation.journalAPOPTOSIS-
dc.contributor.googleauthorLim, Soo-Jeong-
dc.contributor.googleauthorLee, Young-Ju-
dc.contributor.googleauthorPark, Dae-Hun-
dc.contributor.googleauthorLee, Eunmyong-
dc.contributor.googleauthorChoi, Moon-Kyung-
dc.contributor.googleauthorPark, Wanseo-
dc.contributor.googleauthorChun, Kyung-Hee-
dc.contributor.googleauthorChoi, Han-Gon-
dc.contributor.googleauthorCho, Jung Sik-
dc.relation.code2007200817-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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