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dc.contributor.author정승준-
dc.date.accessioned2019-05-28T05:11:57Z-
dc.date.available2019-05-28T05:11:57Z-
dc.date.issued2019-01-
dc.identifier.citationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 116, NO. 5, Page. 1770-1775en_US
dc.identifier.issn0027-8424-
dc.identifier.urihttps://www.pnas.org/content/116/5/1770-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/106125-
dc.description.abstractMajor depressive disorder (MDD) is a devastating disease that arises in a background of environmental risk factors, such as chronic stress, that produce reactive oxygen species (ROS) in the brain. The chronic stress-induced ROS production involves Ca2+ signals; however, the mechanism is poorly understood. Transient receptor potential melastatin type 2 (TRPM2) is a Ca2+-permeable cation channel that is highly expressed in the brain. Here we show that in animal models of chronic unpredictable stress (CUS), deletion of TRPM2 (Trpm2(-/-)) produces antidepressant-like behaviors in mice. This phenotype correlates with reduced ROS, ROS-induced calpain activation, and enhanced phosphorylation of two Cdk5 targets including synapsin 1 and histone deacetylase 5 that are linked to synaptic function and gene expression, respectively. Moreover, TRPM2 mRNA expression is increased in hippocampal tissue samples from patients with MDD. Our findings suggest that TRPM2 is a key agent in stress-induced depression and a possible target for treating depression.en_US
dc.description.sponsorshipWe thank Christopher W. Cowan and David S. Park for providing anti-HDAC5(Ser279) and anti-Prx2(Thr89), respectively. This work was supported by National Research Foundation of Korea Grants 2016R1A2B2006474 (to H.S.) and 2016R1A2B4013332 (to S.J.J.); Basic Science Research Program Grants 2017R1A6A3A01005765 (to S.E.W.) and 2017R1D1A1B03032858 (to M.C.); and Medical Research Center Grant 2017R1A5A2015395 (to H.S.) funded by the Ministry of Science and Technology, Republic of Korea.en_US
dc.language.isoenen_US
dc.publisherNATL ACAD SCIENCESen_US
dc.subjectTRPM2en_US
dc.subjectdepressionen_US
dc.subjectROSen_US
dc.subjectCdk5en_US
dc.subjectneurogenesisen_US
dc.titleTransient receptor potential melastatin 2 governs stress-induced depressive-like behaviorsen_US
dc.typeArticleen_US
dc.relation.no5-
dc.relation.volume116-
dc.identifier.doi10.1073/pnas.1814335116-
dc.relation.page1770-1775-
dc.relation.journalPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-
dc.contributor.googleauthorKo, Seung Yeon-
dc.contributor.googleauthorWang, Sung Eun-
dc.contributor.googleauthorLee, Han Kyu-
dc.contributor.googleauthorJo, Sungsin-
dc.contributor.googleauthorHan, Jinil-
dc.contributor.googleauthorLee, Seung Hoon-
dc.contributor.googleauthorChoi, Miyeon-
dc.contributor.googleauthorJo, Hye-Ryeong-
dc.contributor.googleauthorSeo, Jee Young-
dc.contributor.googleauthorJung, Sung Jun-
dc.relation.code2019002080-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pideurijj-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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