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Cancer Target Gene Screening: a web application for breast cancer target gene screening using multi-omics data analysis

Title
Cancer Target Gene Screening: a web application for breast cancer target gene screening using multi-omics data analysis
Author
이정연
Keywords
cancer target gene screening; multi-omics; survival analysis; clinical implications; breast cancer subtype; genetic aberration
Issue Date
2019-01
Publisher
OXFORD UNIV PRESS
Citation
BRIEFINGS IN BIOINFORMATICS, bbz003, Page. 1-13
Abstract
Breast cancer comprises several molecular subtypes with distinct clinical features and treatment responses, and a substantial portion of each subtype remains incurable. A comprehensive analysis of multi-omics data and clinical profiles is required in order to better understand the biological complexity of this cancer type and to identify new prognostic and therapeutic markers. Thus, there arises a need for useful analytical tools to assist in the investigation and clinical management of the disease. We developed Cancer Target Gene Screening (CTGS), a web application that provides rapid and user-friendly analysis of multi-omics data sets from a large number of primary breast tumors. It allows the investigation of genomic and epigenomic aberrations, evaluation of transcriptomic profiles and performance of survival analyses and of bivariate correlations between layers of omics data. Notably, the genome-wide screening function of CTGS prioritizes candidate genes of clinical and biological significance among genes with copy number alteration, DNA methylation and dysregulated expression by the integrative analysis of different types of omics data in customized subgroups of breast cancer patients. These features may help in the identification of druggable cancer driver genes in a specific subtype or the clinical condition of human breast cancer. CTGS is available at http://ctgs.biohackers.net.
URI
https://academic.oup.com/bib/advance-article/doi/10.1093/bib/bbz003/5299705https://repository.hanyang.ac.kr/handle/20.500.11754/106124
ISSN
1467-5463; 1477-4054
DOI
10.1093/bib/bbz003
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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